132715-05-0

Basic information

• Product Name: Diphenyl-acetic acid (7R,8aS)-2-benzyl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-7-yl ester
• Synonyms: Diphenyl-acetic acid (7R,8aS)-2-benzyl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-7-yl ester
• CAS NO: 132715-05-0
• Molecular Weight: 454.525
• Mol File: 132715-05-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Diphenyl-acetic acid (7R,8aS)-2-benzyl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-7-yl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Diphenyl-acetic acid (7R,8aS)-2-benzyl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-7-yl ester(132715-05-0)
• EPA Substance Registry System: Diphenyl-acetic acid (7R,8aS)-2-benzyl-1,4-dioxo-octahydro-pyrrolo[1,2-a]pyrazin-7-yl ester(132715-05-0)

Safety Data

• Hazardous Substances Data: 132715-05-0(Hazardous Substances Data)

Upstream product

• 51-35-4 4R-4-hydroxyproline 
• 132715-17-4 (2S,4R)-methyl 1-(2-chloroacetyl)-4-hydroxypyrrolidine-2-carboxylate 
• 40216-83-9 L-4-hydroxyproline methyl ester hydrochloride 
• 1760-46-9 diphenylacetic anhydride 
• 132714-97-7 (7R,8aS)-2-benzyl-7-hydroxyhexahydropyrrolo[1,2-a]pyrazine-1,4-dione 

Relevant articles and documents

8-Hydroxylated Derivatives of Diazabicyclononanes, 2,5-Dioxodiazabicyclononanes and Some Related Esters

Pharmacological considerations promted the authors to synthesize a series of 8-hydroxylated optically active derivatives of diazabicyclononanes and of their 2,5-dioxo analogs from trans-4-hydroxy-L-proline.Esterification with appropriate anhydrides led to the corresponding esters with 6S,8R configuration.Inversion of configuration at C-8 was performed using Mitsunobu method and led to the diastereoisomeric series of 6S,8S esters.A tentative pharmacological evaluation was carried out in the area of sedative and spasmolytic activities.