13273-58-0

Basic information

• Product Name: 1,2,4-Oxadiazole, 3-(4-chlorophenyl)-5-(4-methoxyphenyl)-
• CAS NO: 13273-58-0
• Molecular Formula: C15H11ClN2O2
• Molecular Weight: 286.718
• Mol File: 13273-58-0.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 1,2,4-Oxadiazole, 3-(4-chlorophenyl)-5-(4-methoxyphenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-Oxadiazole, 3-(4-chlorophenyl)-5-(4-methoxyphenyl)-(13273-58-0)
• EPA Substance Registry System: 1,2,4-Oxadiazole, 3-(4-chlorophenyl)-5-(4-methoxyphenyl)-(13273-58-0)

Safety Data

• Hazardous Substances Data: 13273-58-0(Hazardous Substances Data)

Upstream product

• 623-03-0 4-Cyanochlorobenzene 
• 100-07-2 4-methoxy-benzoyl chloride 
• 5033-28-3 4-chlorobenzamidoxime 
• 201230-82-2 carbon monoxide 
• 115298-63-0 phenyl(4-methoxyphenyl)iodonium triflate 
• 68451-78-5 C₁₅H₁₃ClN₂O₃ 
• 33341-64-9 N-Chloro-4-chlorobenzamide 
• 16188-13-9 β-imino-β-(p-anisyl)propionitrile 

Downstream Products

• 748771-38-2 4-[3-(4-chloro-phenyl)-[1,2,4]oxadiazol-5-yl]-phenol 

Relevant articles and documents

Mild and efficient one-pot synthesis of 3,5-disubstituted 1,2,4-oxadiazoles from nitriles mediated by K 3PO 4

Potassium phosphate, K3PO4, has been proved to be a cheap, strong, and efficient reagent for the one-pot synthesis of 3,5-disubstituted-1,2,4-oxadiazoles from nitriles and acid chlorides under mild conditions. [Supplementary material

Synthesis and structure-activity relationships of 3,5-diarylisoxazoles and 3,5-diaryl-1,2,4-oxadiazoles, novel classes of small molecule interleukin-8 (IL-8) receptor antagonists

A novel series of 3,5-diarylisoxazole and 3,5-diaryl-1,2,4-oxadiazole IL-8 inhibitors has been identified. These compounds exhibit activity in an IL-8 binding assay as well as in a functional assay of IL-8 induced elastase release from neutrophils. In add

CYCLIZATION AND ACID-CATALYZED HYDROLYSIS OF O-BENZOYLBENZAMIDOXIMES

Kinetics of formation of 1,2,4-oxadiazoles from 24 substitution derivatives of O-benzoylbenzamidoxime have been studied in sulphuric acid and aqueous ethanol media.It has been found that this medium requires introduction of the Hammett H0 function instead of the pH scale beginning as low as from 0.1percent solutions of mineral acids.Effects of the acid concentration, ionic strength, and temperature on the reaction rate and on the kinetic isotope effect have been followed.From these dependences and from polar effects of substituents it was concluded that along with the cyclization to 1,2,4-oxadiazoles there proceeds hydrolysis to benzamidoxime and benzoic acid.The reaction is thermodynamically controlled by the acid-base equilibrium of the O-benzylated benzamidoximes.