13278-24-5

Upstream product

• 344558-48-1 hydroxy-1 tertiobutyl-4 cyclohexane-acetate de methyle 
• 105-36-2 ethyl bromoacetate 
• 98-53-3 4-tercbutyl-cyclohexanone 
• 18291-80-0 trimethylsilyl bromoacetate 

Downstream Products

• 56300-88-0 2-(4-tert-butylcyclohexylidene)acetaldehyde 
• 41498-18-4 2-(4-(tert-butyl)cyclohexylidene)ethanol 
• 28835-96-3 (4-tert-butylcyclohexylidene)acetic acid 
• 116468-86-1 (1-bromo-4-tert-butyl-cyclohexyl)-acetic acid 

Relevant academic research and scientific papers

Composes heterocycliques spiranniques. V. Synthese et etude configurationnelle dans la serie de l'oxa-2 spirodecane

The 8-t-butyl-2-oxaspirodecan-3-one, 8-t-butyl-2-oxaspirodecane and its 3-methylated derivatives were synthesized by different routes starting from methyl 4-t-butylcyclohexanecarboxylate, 4-t-butylmethylenecyclohexane and methyl 4-t-butylcyclohexylidenecyanoacetate.The cis (-CH2O axial) and trans (-CH2O equatorial) isomers were isolated by preparative HPLC ; their configurations were established from (1) the known stereoselectivity of the reaction involved in the cis/trans ratio controlling step (2) their proton and 13C nmr spectra.