13278-41-6

Usage

Molecular Structure

The compound consists of a naphthalene group, an amino group, and a benzoic acid group.

Organic Compound

It is an organic compound, which means it is made up of carbon, hydrogen, and other elements.

Precursor in Synthesis

It is commonly used as a precursor in the synthesis of pharmaceutical drugs and dyes.

Potential Medical Applications

The compound has been studied for its potential use in the treatment of various diseases, including cancer and inflammation.

Chemical Properties

Its chemical structure and properties make it useful in various applications.

Building Block in Organic Synthesis

It is an important building block in organic synthesis.

InChI:InChI=1/C17H13NO2/c19-17(20)14-9-3-4-10-16(14)18-15-11-5-7-12-6-1-2-8-13(12)15/h1-11,18H,(H,19,20)

Upstream product

• 134-32-7 1-amino-naphthalene 
• 16463-38-0 potassium 2-chlorobenzoate 
• 7732-18-5 water 
• 71-41-0 pentan-1-ol 
• 90-11-9 1-Bromonaphthalene 
• 87-25-2 2-ethoxycarbonylaniline 
• 88-67-5 2-Iodobenzoic acid 
• 88-65-3 2-bromobenzoic-acid 
• 1488-42-2 Diphenyliodonium-2-carboxylate 
• 118-91-2 ortho-chlorobenzoic acid 

Downstream Products

• 78938-51-9 2-(Naphthalen-1-ylamino)-benzoic acid 2-[(E)-2,4-dioxo-imidazolidin-1-ylimino]-ethyl ester 
• 24902-12-3 7-phenoxybenzo[c]acridine 
• 1621107-11-6 C₁₈H₁₇NO 
• 1621106-99-7 2-(methyl(naphthalen-1-yl)amino)benzaldehyde 
• 1621107-05-8 methyl 2-(methyl(naphthalen-1-yl)amino)benzoate 
• 55290-88-5 N-[1]naphthyl-anthraniloyl chloride 

Relevant academic research and scientific papers

Effect of Substituent Size and Isomerization on the Polymorphism of 2-(Naphthalenylamino)-benzoic Acids

To probe the effect of substituent size and isomerization on the polymorphism of fenamic acid (FA) derivatives, we synthesized two FA analogues, namely, 2-(naphthalen-1-ylamino)-benzoic acid and 2-(naphthalen-2-ylamino)-benzoic acid (NBAs), and investigat

Design, synthesis, antimicrobial, and anticancer activities of acridine thiosemicarbazides derivatives

Background: Acridine and thiourea derivatives are important compounds in medicinal chemistry due to their diverse biological properties including anticancer and antimicrobial effects. However, literature reveals some side effects associated with use of ac

Discovery of Novel Naphthylphenylketone and Naphthylphenylamine Derivatives as Cell Division Cycle 25B (CDC25B) Phosphatase Inhibitors: Design, Synthesis, Inhibition Mechanism, and in Vitro Efficacy against Melanoma Cell Lines

CDC25 phosphatases play a critical role in the regulation of the cell cycle and thus represent attractive cancer therapeutic targets. We previously discovered the 4-(2-carboxybenzoyl)phthalic acid (NSC28620) as a new CDC25 inhibitor endowed with promising anticancer activity in breast, prostate, and leukemia cells. Herein, we report a structure-based optimization of NSC28620, leading to the identification of a series of novel naphthylphenylketone and naphthylphenylamine derivatives as CDC25B inhibitors. Compounds 7j, 7i, 6e, 7f, and 3 showed higher inhibitory activity than the initial lead, with Ki values in the low micromolar range. Kinetic analysis, intrinsic fluorescence studies, and induced fit docking simulations provided a mechanistic understanding of the activity of these derivatives. All compounds were tested in the highly aggressive human melanoma cell lines A2058 and A375. Compound 4a potently inhibited cell proliferation and colony formation, causing an increase of the G2/M phase and a reduction of the G0/G1 phase of the cell cycle in both cell lines.

7-benz[c]acridine(4-p-fluorophenyl)-1,2,3-triazole as well as preparation method and application thereof

The invention discloses a benz[c]acridine-1,2,3-triazole compound as well as a preparation method and application thereof. The preparation method of the 7-benz[c]acridine-1,2,3-triazole compound comprises the following steps: 1) taking o-bromobenzoic acid

7-p-methoxybenzyl-amino-benzo[c]acridine hydrochloride and preparation method and application thereof

The invention discloses 7-p-methoxybenzyl-amino-benzo[c]acridine hydrochloride which has a structural formula as shown in the specification. The 7-p-methoxybenzyl-amino-benzo[c]acridine hydrochloride has high selectivity, has obvious inhibiting effects on

7-benz[c]acridine(4-p-methoxyphenyl)-1,2,3-triazole as well as preparation method and application thereof

The invention discloses a 7-benz[c]acridine-1,2,3-triazole compound as well as a preparation method and application thereof. The preparation method of the 7-benz[c]acridine-1,2,3-triazole compound comprises the following steps: 1) taking o-bromobenzoic ac

7-benz[c]acridine(4-p-methylphenyl)-1,2,3-triazole and preparation method thereof

The invention discloses a benz[c]acridine-1,2,3-triazole compound as well as a preparation method and application thereof. The preparation method of the 7-benz[c]acridine-1,2,3-triazole compound comprises the following steps: 1) taking o-bromobenzoic acid

7-p-toluene aminobenzo [c] acridine hydrochloride and preparation method and application thereof

The invention discloses 7-p-toluene aminobenzo [c] acridine hydrochloride. The structural formula of the 7-p-toluene aminobenzo [c] acridine hydrochloride is shown in the description, and the 7-p-toluene aminobenzo [c] acridine hydrochloride is high in se

Benzo(c)acridine derivative, and preparation method and use thereof

The invention discloses a benzo(c)acridine derivative, and a preparation method and a use thereof. The chemical title of the benzo(c)acridine derivative is 7-benzo(c)acridinylamidothiourea, and the derivative has a structural formula shown in the descript

7-benzo(c)acridine-p-fluorobenzamidothiourea, preparation method and application thereof

The invention discloses 7-benzo(c)acridine-p-fluorobenzamidothiourea, a preparation method and an application thereof, wherein the compound has the following structure formula. The invention also provides the application of the compound in preparation of