24902-12-3Relevant academic research and scientific papers
DESIGN, SYNTHESIS, AND BIOLOGICAL ACTIVITY OF PLATINUM-BENZ[C]ACRIDINE HYBRID AGENTS AND METHODS ASSOCIATED THEREWITH
-
, (2015/11/10)
The present invention relates to the compounds of formula (I), pharmaceutically acceptable salts, and solvates thereof, wherein the various substituents are as defined herein. The compounds, solvates and salts thereof of Formula (I) are effective as anti-cancer compounds.
Redesigning the DNA-Targeted chromophore in platinum-acridine anticancer agents: A structure-activity relationship study
Pickard, Amanda J.,Liu, Fang,Bartenstein, Thomas F.,Haines, Laura G.,Levine, Keith E.,Kucera, Gregory L.,Bierbach, Ulrich
supporting information, p. 16174 - 16187 (2015/02/19)
Platinum-acridine hybrid agents show low-nano-molar potency in chemoresistant non-small cell lung cancer (NSCLC), but high systemic toxicity in vivo. To reduce the promiscuous genotoxicity of these agents and improve their pharmacological properties, a mo
