132839-05-5

Usage

InChI:InChI=1/C10H10Cl2N2O2/c1-2-16-10(15)9(12)14-13-8-5-3-7(11)4-6-8/h3-6,13H,2H2,1H3/b14-9+

Upstream product

• 623-73-4 diazoacetic acid ethyl ester 
• 17333-85-6 4-chlorophenyldiazonium salt 
• 18794-97-3 ethyl 2-(4-chlorophenylhydrazono)-3-oxobutyrate 
• 106-47-8 4-chloro-aniline 
• 609-15-4 ethyl 2-chloro-3-oxo-butyrate 
• 2028-74-2 p-chlorobenzenediazonium chloride 
• 105-39-5 chloroacetic acid ethyl ester 
• 7782-50-5 chlorine 
• 10475-63-5 3-oxo-2-(phenylhydrazono)butyric acid ethyl ester 
• 7791-25-5 sulfuryl dichloride 
• 127-09-3 sodium acetate 

Downstream Products

• 76795-07-8 4-(4-Chloro-phenyl)-5-imino-4,5-dihydro-[1,3,4]selenadiazole-2-carboxylic acid ethyl ester 
• 1529-04-0 p-Toluolsulfonyl-glyoxylsaeure-aethylester-<4-chlor-phenylhydrazon> 
• 76795-27-2 5-[(Z)-Acetylimino]-4-(4-chloro-phenyl)-4,5-dihydro-[1,3,4]selenadiazole-2-carboxylic acid ethyl ester 
• 1261065-39-7 ethyl 3-(p-chlorophenylamino)-4-oxo-3,5,6,7-tetrahydro-4H-cyclopenta[4,5]thieno[2,3-d]pyrimidine-2-carboxylate 
• 1261065-47-7 ethyl 3-(p-chlorophenylamino)-4-oxo-3,5,6,7,8,9-hexahydro-4H-cyclohepta[4,5]thieno[2,3-d]pyrimidine-2-carboxylate 
• 1310876-54-0 4-(8,9-dimethoxy-1-phenyl-1,5,6,10b-tetrahydro[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)-2-(4-chlorophenyl)-2,6-dihydropyrazolo[3,4-d]pyridazin-7-one 
• 1309462-40-5 ethyl 5-oxo-6-[(1,7-diphenyl-1,5-dihydro-5-oxo-[1,2,4]triazolo[4,3-a]pyrimidin-3-yl)]-1-(4-chlorophenyl)-1,5-dihydropyrido[2,3-d][1,2,4]triazolo[4,3-a]pyrimidine-3-carboxylate 

Relevant academic research and scientific papers

Novel 4-phenoxypyridine derivatives bearing imidazole-4-carboxamide and 1,2,4-triazole-3-carboxamide moieties: Design, synthesis and biological evaluation as potent antitumor agents

Two series of novel 4-phenoxypyridine derivatives containing imidazole-4-carboxamide and 4-methyl-5-oxo-4,5-dihydro-1,2,4-triazole-3-carboxamide moieties were synthesized and evaluated for their in vitro inhibitory activities against c-Met kinase and anti

Design, synthesis and anti-tumor evaluation of 1,2,4-triazol-3-one derivatives and pyridazinone derivatives as novel CXCR2 antagonists

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Triadimefon compound and uses thereof

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Separation of PALMITIC acid from over used oil for production of heterogeneous organic derivatives of potential biological activities

PALMITIC acid was extracted from Over-used cooking oil where oil was filtered off, then it was hydrolyzed with distilled water in high pressure reactor at 250°C and 2 MPa to produce glycerol and mixture of fatty acids. Fatty acids mixture was cooled at 7°C in order to precipitate all saturated fatty acids, which were then filtered off, Palmitic acid was extracted from this mixture by means of supercritical CO2 extractor at 35.0 MPa and 55°C, followed by its methylation and confirmation by GC mass. Then it was used as precursor for production of a different heterocyclic compounds which were then tested for their antimicrobial activities. Thus the long-chain methyl palmitate was interacted with hydrazine hydrate to produce the corresponding acid hydrazide (2), and then it was treated with phenyl isothiocyanate, furnished the corresponding thiosemicarbazide 4. The later was reacted with ethyl chloro(arylhydrazono) acetate 5a-b in dimethylformamide, in the presence of triethylamine, afforded thiadiazole derivatives 7a-b. A solution of thiosemicarbazide 4 in ethanol was interacted with the a-haloketones 9 in the presence of triethylamine, produced the parallel thiadiazine 12. The structure elucidation of all synthesized compounds is based on the elemental analysis and spectral data (IR, 1H NMR, 13C NMR and MS).

Design, synthesis, and structure–activity relationship of novel and effective apixaban derivatives as FXa inhibitors containing 1,2,4-triazole/pyrrole derivatives as P2 binding element

Four series of novel and potent FXa inhibitors possessing the 1,2,4-triazole moiety and pyrrole moiety as P2 binding element and dihydroimidazole/tetrahydropyrimidine groups as P4 binding element were designed, synthesized, and evaluated for their anticoagulant activity in human and rabbit plasma in vitro. Most compounds showed moderate to excellent activity. Compounds 14a, 16, 18c, 26c, 35a, and 35b were further examined for their inhibition activity against human FXa in vitro and rat venous thrombosis in vivo. The most promising compound 14a, with an IC50(FXa) value of 0.15?μM and 99% inhibition rate, was identified for further evaluation as an FXa inhibitor.

4,5-dihydropyrazolo [3,4-c] pyridine-2-one spiro derivatives, its preparation method and application

Disclosed are a spirocyclic derivative of 4,5-dihydropyrazolo[3,4-c]pyridine-2-one as represented by general formula (I), preparation method and use thereof, the definition of each substituent in the compound of general formula (I) being the same as the definition in the description.

Optimization of non-ATP competitive CDK/cyclin groove inhibitors through REPLACE-mediated fragment assembly

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