132849-69-5

Upstream product

• 20535-16-4 (2R,3S,4R,5R)-2-(6-amino-9H-purin-9-yl)-4-fluoro-5-(hydroxymethyl)tetrahydrofuran-3-ol 
• 98-88-4 benzoyl chloride 
• 69304-45-6 3',5'-O-(1,1,3,3-tetra-isopropyldisiloxane-1,3-diyl)adenosine 
• 137965-10-7 (2R,3R,4R,5R)-2-(hydroxymethyl)-5-(6-(tritylamino)-9H-purin-9-yl)-4-(trityloxy)tetra-hydrofuran-3-ol 

Downstream Products

• 132849-70-8 N⁶-Benzoyl-9-<3'-deoxy-3'-fluoro-5'-O-(monomethoxytrityl)-β-D-xylofuranosyl>adenine 
• 168918-60-3 9-<2-O-Benzoyl-3-fluoro-3-deoxy-5-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶,N⁶-dibenzoyladenine 
• 168918-64-7 9-<3-Fluoro-3-deoxy-5-O-(monomethoxytrityl)-β-D-xylofuranosyl>-N⁶-benzoyladenine 2'-<2-chlorophenyl 2-(4-nitrophenyl)ethyl phosphate> 
• 168918-62-5 9-(2-O-Benzoyl-3-fluoro-3-deoxy-β-D-xylofuranosyl)-N⁶,N⁶-dibenzoyladenine 
• 132849-71-9 N⁶-Benzoyl-9-<2'-O-<(tert-butyl)dimethylsilyl>-3'-deoxy-3'-fluoro-β-D-xylofuranosyl>adenine 

Relevant academic research and scientific papers

LOCKED NUCLEIC ACID CYCLIC DINUCLEOTIDE COMPOUNDS AND USES THEREOF

The present invention provides highly active locked nucleic acid cyclic-dinucleotide (LNA-CDN) immune stimulators that activate DCs via the cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the LNA-CDNs of the present in

COMPOSITIONS AND METHODS FOR ACTIVATING "STIMULATOR OF INTERFERON GENE"-DEPENDENT SIGNALLING

The present invention provides highly active cyclic-di-nucleotide (CDN) immune stimulators that activate DCs via a recently discovered cytoplasmic receptor known as STING (Stimulator of Interferon Genes). In particular, the CDNs of the present invention are provided in the form of a composition comprising one or more cyclic purine dinucleotides induce human STING-dependent type I interferon production, wherein the cyclic purine dinuclotides present in the composition are 2'- or 3'-mono-fluoro substituted, or 2'3'-di-fluoro substituted mixed linkage 2',5' - 3',5' CDNs.

Role of the stereochemistry of 3'-fluoro-3'-deoxy analogues of 2-5A in binding to and activation of mouse RNase L

The synthesis of two sets of analogues of 2-5A trimer containing 9-(3-fluoro-3-deoxy-β-D-xylo-furanosyl)adenine (AF) or 3'-fluoro-3'-deoxyadenosine (AF) at different positions of the chain is described, along with the preparation of the corresponding 5'-monophosphates and 5'-diphosphorylated (core) trimers.The ability of each ribo and xylo isomeric pair of fluorodeoxy analogues of 2-5A (i) to compete with p3(A2'p)3A3'pC3'p for binding to RNase L in L929 cell extracts, and (ii) to activate the partially purified RNase L from L929 cell extracts to hydrolyze poly(U), was compared to that of the related 3'-deoxy analogue and the parent trimer, p3A3, using radiobinding and RNase L-(2',5')pentaadenylate(core)-agarose assays, respectively.Evidence is presented to show that the stereochemistry of the trimers plays an important role, specifically in the second process.The most striking observation is that, compared to 2-5A, p3A(AF)A was found to be nine times more effective an activator of RNase L, whereas isomeric p3A(AF)A is 30 times less effective.