13286-65-2

Basic information

• Product Name: Trans-1-Amino-2-TeTralol
• Synonyms: Trans-1-Amino-2-TeTralol;(1R,2R)-1-Amino-1,2,3,4-tetrahydronaphthalen-2-ol
• CAS NO: 13286-65-2
• Molecular Formula: C₁₀H₁₃NO
• Molecular Weight: 163.21632
• Mol File: 13286-65-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 105 °C
• Boiling Point: 310.2±42.0 °C(Predicted)
• Appearance: /
• Density: 1.159±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 14.67±0.40(Predicted)
• CAS DataBase Reference: Trans-1-Amino-2-TeTralol(CAS DataBase Reference)
• NIST Chemistry Reference: Trans-1-Amino-2-TeTralol(13286-65-2)
• EPA Substance Registry System: Trans-1-Amino-2-TeTralol(13286-65-2)

Safety Data

• Hazardous Substances Data: 13286-65-2(Hazardous Substances Data)

Upstream product

• 117886-33-6 (3ar,9bc)-3a,4,5,9b-tetrahydro-naphtho[1,2-d]oxazol-2-ylamine 
• 109367-26-2 (+/-)-2-(4-nitro-phenyl)-(3ar,9bc)-3a,4,5,9b-tetrahydro-naphth[1,2-d]oxazole 
• 2461-34-9 1,2-epoxy-3,4-dihydronaphthalene 
• 64245-04-1 2-bromo-1-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 2018-87-3 1,2-dibromo-1,2,3,4-tetrahydro-naphthalene 
• 447-53-0 1,2-Dihydronaphthalene 
• 39834-40-7 trans-2-bromo-1,2,3,4-tetrahydronaphthalen-1-ol 
• 2461-34-9 1a,2,3,7b-tetrahydronaphtho[1,2-b]oxirene 
• 2018-87-3 (+/-)-trans-1,2-dibromo-1,2,3,4-tetrahydronaphthalene 
• 14211-53-1 cis-1,2-dihydroxy-1,2,3,4-tetrahydronaphthalene 
• 7480-36-6 (+/-)-trans-1-amino-2-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 915131-33-8 (+/-)-3,4-dihydro-2-hydroxy-1H-naphthalen-1-one oxime 
• 64559-97-3 2-hydroxy-1-tetralone 
• 745072-29-1 2-phenyl-3a,8,9,9a-tetrahydronaphtho[1,2-d]oxazole 

Downstream Products

• 7480-36-6 (+/-)-cis-1-amino-2-hydroxy-1,2,3,4-tetrahydronaphthalene 
• 745072-29-1 2-phenyl-3a,8,9,9a-tetrahydronaphtho[1,2-d]oxazole 
• 86800-08-0 trans-N-Benzyl-α-amino-β-tetralol 
• 109470-12-4 trans-1-Benzoylamino-2-hydroxy-tetralin 
• 86800-08-0 cis-N-Benzyl-α-amino-β-tetralol 
• 141034-11-9 trans-N-(2-hydroxy-1,2,3,4-tetrahydronaphthalene-1-yl)-N'-benzoyl thiourea 
• 141034-17-5 trans-2-imino-3-acetyl thiazolidine 
• 141034-15-3 trans-2-iminothiazolidine 
• 141034-13-1 trans-N-(2-hydroxy-1,2,3,4-tetrahydronaphthalene-1-yl) thiourea 

Relevant articles and documents

BICYCLIC UREA, THIOUREA, GUANIDINE AND CYANOGUANIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF PAIN

Compounds of Formula I: or stereoisomers, tautomers, or pharmaceutically acceptable salts, solvates or prodrugs thereof, wherein Ring A, Ring C and X are as defined herein, are inhibitors of TrkA kinase and are useful in the treatment of diseases which can be treated with a TrkA kinase inhibitor such as pain, cancer, inflammation/inflammatory diseases, neurodegenerative diseases, certain infectious diseases, Sjogren's syndrome, endometriosis, diabetic peripheral neuropathy, prostatitis and pelvic pain syndrome.

Asymmetric synthesis of chiral 1,3-diaminopropanols: Bisoxazolidine- catalyzed C-C bond formation with α-keto amides

Three high-yielding steps lead to the formation of chiral 1,3-diaminopropanols from aliphatic and aromatic α-keto amides. In this approach, a nitroaldol reaction, which is catalyzed by Cu(SO2CF 3)2 and the bisoxazolidine ligand L1, is followed by two mild reduction reactions (see scheme). Laborious protection and deprotection steps can be avoided by using this method.

Synthesis of tetrahydronaphthyl thioureas as potent appetite suppressants

A series of thiourea derivatives (7-23, 25-27) of 1- aminotetrahydronaphthalene (4) and 1-amino-2-hydroxytetrahydronaphthalene (5) were synthesized in single pot in 48-90% yield and evaluated for their anorexigenic activity. Among them compounds 10, 14, 15, 16 and 22 exhibited significant anorexigenic activity without any antidepressant effect and provided a new structural lead for appetite suppressants.