132871-12-6

Basic information

• Product Name: (S)-2-METHYL-4-BENZYLPIPERAZINE
• Synonyms: (S)-2-METHYL-4-BENZYLPIPERAZINE;4-N-BENZYL-2-(S)-METHYLPIPERAZINE;Piperazine, 3-methyl-1-(phenylmethyl)-, (3S)- (9CI);(3S)-1-BENZYL-3-METHYLPIPERAZINE;1-Benzyl-3(S)-methylpiperazine;(3S)-3-Methyl-1-(phenylmethyl)piperazine;AB3085;(3S)-3-Methyl-1-(phenylmethyl)piperazine,99%e.e.
• CAS NO: 132871-12-6
• Molecular Formula: C₁₂H₁₈N₂
• Molecular Weight: 190.28
• Product Categories: PIPERIDINE;pharmacetical
• Mol File: 132871-12-6.mol
• Article Data: 9

Chemical Properties

• Melting Point: 31-33 °C
• Boiling Point: 282℃
• Flash Point: 112℃
• Appearance: /
• Density: 0.991
• Vapor Pressure: 0.00354mmHg at 25°C
• Refractive Index: 1.529
• PKA: 9.31±0.40(Predicted)
• CAS DataBase Reference: (S)-2-METHYL-4-BENZYLPIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-2-METHYL-4-BENZYLPIPERAZINE(132871-12-6)
• EPA Substance Registry System: (S)-2-METHYL-4-BENZYLPIPERAZINE(132871-12-6)

Safety Data

• Hazardous Substances Data: 132871-12-6(Hazardous Substances Data)

Usage

General Description

(S)-2-Methyl-4-benzylpiperazine is a chemical compound with the molecular formula C13H18N2. It is a piperazine derivative with a methyl group and a benzyl group attached to the nitrogen atom. (S)-2-METHYL-4-BENZYLPIPERAZINE is commonly used in pharmacology and medicinal chemistry as a building block for the synthesis of various pharmaceutical drugs and biologically active molecules. It has been studied for its potential therapeutic applications in treating conditions such as anxiety, depression, and neurological disorders. Additionally, (S)-2-methyl-4-benzylpiperazine has been investigated for its potential as a drug delivery vehicle and as a targeting ligand in drug design. Overall, this compound plays a crucial role in the development of new pharmaceutical compounds and drug delivery systems.

InChI:InChI=1/C12H18N2/c1-11-9-14(8-7-13-11)10-12-5-3-2-4-6-12/h2-6,11,13H,7-10H2,1H3/t11-/m0/s1

Upstream product

• 74879-18-8 (S)-2-methylpiperazine 
• 100-39-0 benzyl bromide 
• 100-46-9 benzylamine 
• 6436-90-4 ethyl 2-(benzylamino)acetate 
• 118375-95-4 methyl (S)-2-(2-chloroacetamido)propanoate 
• 104-63-2 N-Benzylethanolamine 
• 170033-54-2 (S)-<2-<(2-Hydroxyethyl)(phenylmethyl)amino>-1-methyl-2-oxoethyl>carbamic acid 1,1-dimethylethyl ester 
• 86666-85-5 N^α-Boc-Ala-N^α-benzylglycine ethyl ester 
• 132871-10-4 (3S)-1-benzyl-3-methylpiperazine-2,5-dione 
• 170033-57-5 (S)-3-Methyl-1-(phenylmethyl)piperazin-2-one 
• 761357-45-3 [((S)-2-Amino-propionyl)-benzyl-amino]-acetic acid ethyl ester 

Downstream Products

• 169447-69-2 tert-Butyl (S)-2-methyl-4-(phenylmethyl)-1-piperazinecarboxylate 
• 400786-02-9 (S)-2-(4-benzyl-2-methyl-piperazin-1-yl)-quinoxaline 
• 400785-91-3 (S)-2-(4-benzyl-2-methyl-piperazin-1-yl)-4-methoxymethyl-6-methyl-pyrimidine 
• 400786-01-8 (S)-2-(4-benzyl-2-methyl-piperazin-1-yl)-oxazolo[5,4-c]pyridine 
• 400785-78-6 1R-[4-(4-benzyl-2S-methyl-piperazin-1-yl)pyrimidin-2-yl]ethyl butyrate 
• 300552-28-7 (S)-2-(4-benzyl-2-methyl-piperazin-1-yl)-oxazolo[5,4-b]pyridine 
• 1018829-31-6 (2S)-4-benzyl-1-(4-bromo-3-methylphenyl)-2-methylpiperazine 
• 511255-00-8 4-(4-chloro-phenyl)-3-(S)-methyl-piperazine 
• 169447-70-5 (S)-2-methyl-piperazine-1-carboxylic acid tert-butyl ester 
• 511254-97-0 (S)-4-benzyl-1-(4-chlorophenyl)-2-methylpiperazine 

Relevant articles and documents

Structure-Activity Relationship Studies on Oxazolo[3,4- a]pyrazine Derivatives Leading to the Discovery of a Novel Neuropeptide S Receptor Antagonist with Potent in Vivo Activity

Neuropeptide S modulates important neurobiological functions including locomotion, anxiety, and drug abuse through interaction with its G protein-coupled receptor known as neuropeptide S receptor (NPSR). NPSR antagonists are potentially useful for the treatment of substance abuse disorders against which there is an urgent need for new effective therapeutic approaches. Potent NPSR antagonists in vitro have been discovered which, however, require further optimization of their in vivo pharmacological profile. This work describes a new series of NPSR antagonists of the oxazolo[3,4-a]pyrazine class. The guanidine derivative 16 exhibited nanomolar activity in vitro and 5-fold improved potency in vivo compared to SHA-68, a reference pharmacological tool in this field. Compound 16 can be considered a new tool for research studies on the translational potential of the NPSergic system. An in-depth molecular modeling investigation was also performed to gain new insights into the observed structure-activity relationships and provide an updated model of ligand/NPSR interactions.

Enantiomerically pure piperazines via NaBH4/I2reduction of cyclic amides

Enantiomerically pure (3S,7R,8aS)-3-phenyloctahydropyrrolo[1,2-a]pyrazine-7-ol, (3S,7R,8aS)-3-methyl octahydropyrrolo[1,2-a]pyrazine-7-ol, (3S,7R,8aS)-3-isopropyloctahydropyrrolo[1,2-a]pyrazine-7-ol and (3S,7R,8aS)-3-isobutyloctahydropyrrolo[1,2-a]pyrazine-7-ol 16d were synthesized via preparation of the corresponding cyclic amides from enantiomerically pure L-proline and hydroxyproline derivatives followed by reduction using sodium borohydride-iodine.

PIPERAZINE UREA DERIVATIVES AS MELANOCORTIN-4 RECEPTOR AGONISTS

Certain novel piperazine urea derivatives are agonists of the human melanocortin-4 receptor (MC-4R) and, in particular, are receptor-subtype selective agonists of MC-4R. They are useful for the treatment, control, or prevention of diseases and disorders r