132871-52-4

Upstream product

• 19881-97-1 3-phenylpropane-1,2-diol 
• 4436-24-2 1,2-epoxy-3-phenylpropane 
• 35948-04-0 1-azido-3-phenylpropan-2-one 
• 20772-12-7 1-bromo-3-phenyl-2-propanone 
• 300-57-2 allylbenzene 

Downstream Products

• 35948-04-0 1-azido-3-phenylpropan-2-one 
• 132894-45-2 (1-azido-3-phenylpropan-2-yloxy)(tert-butyl)dimethylsilane 
• 50411-26-2 3-phenyl-2-hydroxypropylamine 
• 132871-57-9 2-(tert-Butyl-dimethyl-silanyloxy)-3-phenyl-propylamine 
• 13906-90-6 2-benzylaziridine 
• 883545-49-1 2-methoxy-3-phenylpropan-1-amine 
• 1338685-20-3 10-[2-(benzyloxy)-3-phenylpropyl]-7,8-dimethylbenzo[g]pteridine-2,4(3H,10H)-dione 
• 1338685-24-7 N-[2-(benzyloxy)-3-phenylpropyl]-4,5-dimethylbenzene-1,2-diamine 
• 1338685-23-6 N-[2-(benzyloxy)-3-phenylpropyl]-4,5-dimethyl-2-nitroaniline 
• 1338685-22-5 2-(benzyloxy)-3-phenylpropan-1-amine 

Relevant academic research and scientific papers

Do GluN2B subunit containing NMDA receptors tolerate a fluorine atom in the phenylalkyl side chain?

The influence of an F-atom in the side chain of benzo[7]annulen-7-amines on the affinity towards GluN2B subunit containing NMDA receptors and the selectivity over related receptors was investigated. The synthesis of 5a and 5b was performed by reductive am

Copper-catalyzed ring-opening reactions of alkyl aziridines with b2 pin2: Experimental and computational studies

The possibility to form new C–B bonds with aziridines using diboron derivatives con-tinues to be a particularly challenging field in view of the direct preparation of functionalized β-aminoboronates, which are important compounds in drug discovery, being a bioisostere of β-aminoacids. We now report experimental and computational data that allows the individua-tion of the structural requisites and of reaction conditions necessary to open alkyl aziridines using bis(pinacolate)diboron (B2 pin2 ) in a regioselective nucleophilic addition reaction under copper catalysis.

Azidolysis of epoxides catalysed by the halohydrin dehalogenase from Arthrobacter sp. AD2 and a mutant with enhanced enantioselectivity: an (S)-selective HHDH

Halohydrin dehalogenase from Arthrobacter sp. AD2 catalysed azidolysis of epoxides with high regioselectivity and low to moderate (S)-enantioselectivity (E?=?1–16). Mutation of the asparagine 178 to alanine (N178A) showed increased enantioselectivity towards styrene oxide derivatives and glycidyl ethers. Conversion of aromatic epoxides was catalysed by HheA-N178A with complete enantioselectivity, however the regioselectivity was reduced. As a result of the enzyme-catalysed reaction, enantiomerically pure (S)-β-azido alcohols and (R)-α-azido alcohols (ee???99%) were obtained.

Catalytic transformation of esters of 1,2-azido alcohols into α-amido ketones

The esters of 1,2-azido alcohols were transformed into α-amido ketones without external oxidants through the Ru-catalyzed formation of N-H imines with the liberation of N2 followed by intramolecular migration of the acyl moiety. A wide range of α-amido ketones were obtained, and one-pot transformation into the corresponding oxazoles (or a thiazole) was demonstrated.

Characterization and utility of N-unsubstituted imines synthesized from alkyl azides by ruthenium catalysis

Shine a light: A fluorescent light-induced synthetic method for the title compounds has been developed and the chemoselective nature of the reaction is highlighted by the observation of the cis/trans isomers of various N-unsubstituted imines. The synthetic utility of this method is demonstrated by the one-pot imine formation/asymmetric allylation sequence of benzyl azide catalyzed by 1. (Ipc=isopinocampheyl). Copyright

FLAVIN DERIVATIVES

The present invention relates novel flavin derivatives, their use and compositions for use as riboswitch ligands and/or anti-infectives.

Intramolecular reductive amination strategy to the synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-2-benzylmorpholine

A concise high yielding enantioselective synthesis of (R)-N-Boc-2-hydroxymethylmorpholine, N-(3,4-dichlorobenzyl)(R)-2-hydroxymethylmorpholine, and (R)-benzylmorpholine has been achieved by employing proline-catalyzed asymmetric α-aminooxylation of aldehyde and palladium-catalyzed intramolecular reductive amination of azido aldehyde as the key steps.

Substituted heterocyclic compounds and methods of use

The present invention relates to compounds having the general formula or a pharmaceutically acceptable salt thereof, wherein R1 is a saturated or unsaturated 5-, 6- or 7-membered, ring containing 0, 1, 2 or 3 atoms selected from N, O and S, whe

BETA-AMINO HETEROCYCLIC DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to compounds which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.

Dynamic kinetic resolution of β-azido alcohols. An efficient route to chiral aziridines and β-amino alcohols

Enzymatic resolution of β-azido alcohols in combination with ruthenium-catalyzed alcohol isomerization led to a successful dynamic kinetic resolution. A variety of racemic β-azido alcohols were efficiently transformed to the corresponding enantiomerically pure acetates (ee up to 99% and conversion up to 98%). The synthetic utility of this procedure has been illustrated by the practical synthesis of (S)-propanolol I and (R)-β-azido-α-(4-methoxyphenyl)ethanol ((R)-1c), a direct precursor of denopamine II.