13288-40-9Relevant academic research and scientific papers
Bifunctional bisphosphonate derivatives and platinum complexes with high affinity for bone hydroxyapatite
Sun, Yanyan,Chen, Lei,Wu, Xiwen,Ding, Qian
, p. 1070 - 1075 (2017)
A series of ethylenediamine/1,3-propanediamine derivatives containing bifunctional bisphosphonate substituents and their corresponding dichloroplatinum(II) complexes have been synthesized and characterized by elemental analysis, 1H NMR, 13C NMR, 31P NMR, and HRMS spectra. Based on WST-8 assay with CCK-8, in general, the newly synthesized dichloroplatinum complexes 1–6 showed higher in vitro antitumor activity than platinum-free compounds L1–L6 against three tumor cell lines (especially osteosarcoma MG-63). According to hydroxyapatite binding experiment, complexes 2, 3, and 6 showed much higher affinity (K′ = 3.7, 4.0, and 3.0, respectively) for bone hydroxyapatite than cisplatin (K′ 0.1), comparable to zoledronate (K′ = 2.8). It can be found that representative complex 2 with high cytotoxicity and in vitro antiproliferative activity against osteosarcoma cell line, as well as promising hydroxyapatite binding ability has been screened as a potential bone-targeting antitumor agent for subsequent in vivo study. In addition, flow cytometry experiment was applied to investigate the mode of action of representative complex 2.
Synthesis, molecular structure and spectral analysis: DFT-TDDFT computational study of ruthenium complex of tetradentate N,N′- bis(benzimidazole-2yl-ethyl)-ethylenediamine
Guadalupe, Hernández J.,Narayanan, Jayanthi,Pandiyan, Thangarasu
experimental part, p. 70 - 79 (2011/05/03)
Ruthenium complex of N,N′-bis(benzimidazol-2-yl-ethyl)ethylenediamine (L1) was prepared and characterized by analytical methods. Structural and spectral properties of N,N′-bis(benzimidazol-2-yl-ethyl) ethylenediamine (L1), its dianio
Method and apparatus for sunless tanning
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, (2008/06/13)
Apparatus for simulating skin tanning comprises a receptacle containing a fluid comprising dihydroxyacetone, a receptacle containing a fluid comprising a secondary polyamine, and dispensing means for simultaneously or sequentially providing desired amounts of dihydroxyacetone and polyamine.
Synthesis of certain multidentate benzimidazole-derived ligands
Sivagnanam, Usha,Pandiyan, Thangarasu,Palaniandavar, Mallayan
, p. 572 - 576 (2007/10/02)
Synthetic procedures are described for obtaining various multidentate ligands incorporating benzimidazole moieties.The benzimidazoles were obtained by the condensation of acids with o-phenylenediamines.Syntheses are reported for N,N-bis(1-methylbenzimidazol-2-ylmethyl)amine (2), N,N'-bis(1-methylbenzimidazol-2-ylethyl)ethylenediamine (5), N,N,N',N'-tetrakis(benzimidazol-2-ylmethyl)-1,2-diaminocyclohexane (6), N,N,N',N'-tetrakis(4-methylbenzimidazol-2-ylmethyl)-1,2-diaminocyclohexane (7), HOOC-(CH2)m-S-CH2-CH2-S-(CH2)n-S-Ch2-CH2-S-(CH2)m-COOH , BzIm-(CH2)m-S-CH2-CH2-S-(CH2)n-S-CH2-CH2-S-(CH2)m-BzIm , HOOC-CH2-S-(CH2-CH2-S)4-CH2-COOH (15) and BzIm-CH2-S-(CH2-CH2-S)4-CH2-BzIm (16).
Hydroformylation of olefins using azoxy-dentated ligands
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, (2008/06/13)
At a temperature in the range 100° C to 225° C the destructive dissociation of cobalt carbonyl compounds to cobalt metal and residue is inhibited by the action of one or more azoxy-dentated chelation ligands.
