132883-46-6

Upstream product

• 98516-10-0 acetic acid (1R,6S)-6-hydroxymethyl-cyclohex-3-enylmethyl ester 
• 439919-46-7 cis-1,6-dihydroxymethyl-3-cyclohexene 
• 558-13-4 carbon tetrabromide 
• 935-79-5 cis-1,2,3,6-tetrahydrophthalic anhydride 
• 954148-36-8 (1R,2S)-[2-[(acetyloxy)methyl]cyclohex-4-en-1-yl]methyl acetate 

Downstream Products

• 132883-47-7 (1R,2R)-1-methanol-2-acetonitrile-4-cyclohexene acetate 
• 132883-48-8 (1R,2R)-1-methanol-2-acetonitrile-4-cyclohexene 
• 132883-49-9 (1R,2R)-1-methanol-2-acetonitrile-4-cyclohexene mesylate 
• 132846-00-5 cis-(4aR,8aR)-2-benzyloxycarbonyl-1,2,3,4,4a,5,8,8a-octahydroisoquinoline 

Relevant academic research and scientific papers

Resolution and stereoselective synthesis of the herpes thymidine kinase inhibitor L-653180

Resolution of L-653180, (±)-9-{[(Z)-2-(hydroxymethyl)cyclohexyl]-methyl}guanine, a racemic, nonsubstrate inhibitor of HSV-TK, was achieved and the absolute stereochemistry of the enantiomers was determined. Enzyme inhibition was shown to reside in the ena

An efficient chemo-enzymatic approach to (+)-meroquinene

Meroquinone (+)-1 was prepared in an efficient and stereocontrolled fashion from (-)-(1R-2S)-4-cyclohexene dimethanol monoacetate (-)-8. Key steps are the enzyme-catalyzed hydrolysis of the available diacetate 5 to (-)-8 and of the intermediate diester 17