132883-47-7

Upstream product

• 151-50-8 potassium cyanide 
• 98516-10-0 acetic acid (1R,6S)-6-hydroxymethyl-cyclohex-3-enylmethyl ester 
• 132883-46-6 (1S,2R)-1-bromomethyl-2-methanol-4-cyclohexene acetate 

Downstream Products

• 132846-05-0 (3R,4S)-4-Methoxycarbonylmethyl-3-[2-(2-nitro-phenylselanyl)-ethyl]-piperidine-1-carboxylic acid benzyl ester 
• 132846-02-7 (3R,4S)-1-benzyloxycarbonyl-3,4-piperidine diacetic acid dimethyl ester 
• 132846-03-8 (3R,4S)-3-Carboxymethyl-4-methoxycarbonylmethyl-piperidine-1-carboxylic acid benzyl ester 
• 132846-01-6 (3R,4S)-1-benzyloxycarbonyl-3,4-piperidine diacetic acid 
• 132846-04-9 (3R,4S)-3-(2-Hydroxy-ethyl)-4-methoxycarbonylmethyl-piperidine-1-carboxylic acid benzyl ester 
• 132846-06-1 N-benzyloxycarbonyl meroquinene methyl ester 
• 132846-00-5 cis-(4aR,8aR)-2-benzyloxycarbonyl-1,2,3,4,4a,5,8,8a-octahydroisoquinoline 
• 132883-49-9 (1R,2R)-1-methanol-2-acetonitrile-4-cyclohexene mesylate 
• 132883-48-8 (1R,2R)-1-methanol-2-acetonitrile-4-cyclohexene 

Relevant academic research and scientific papers

An efficient chemo-enzymatic approach to (+)-meroquinene

Meroquinone (+)-1 was prepared in an efficient and stereocontrolled fashion from (-)-(1R-2S)-4-cyclohexene dimethanol monoacetate (-)-8. Key steps are the enzyme-catalyzed hydrolysis of the available diacetate 5 to (-)-8 and of the intermediate diester 17

A Highly Enantioselective Synthesis of (-)-Antirhine by Chemo-Enzymatic Approach

(-)-Antirhine 2 was synthesized in an efficient and stereocontrolled fashion from the readily available (1R-2S)-cyclohexene dimethanol monoacetate 6.A key step was the regio- and stereoselective Pictet Spengler cyclization of the masked dialdehyde 12 to t