132906-25-3

Upstream product

• 778-82-5 ethyl 3-indoleacetate 
• 74-89-5 methylamine 
• 87-51-4 indole-3-acetic acid 
• 879-37-8 3-indolylacetamide 
• 74-88-4 methyl iodide 
• 885117-59-9 methyl 3-(2-(methylamino)-2-oxoethyl)-1H-indole-1-carboxylate 
• 1912-33-0 Indole-3-acetic acid methyl ester 

Downstream Products

• 1383933-74-1 (3aS,8aR)-1-methyl-3a-phenyl-3,3a,8,8a-tetrahydropyrrolo[2,3-b]indol-2(1H)-one 

Relevant academic research and scientific papers

A catalytic N-deacylative alkylation approach to hexahydropyrrolo[2,3-b]indole alkaloids

A versatile unprecedented strategy to diversely functionalized hexahydropyrrolo[2,3-b]indole alkaloids is described in high chemical yields. The synthesis features a key Pd(0)-catalyzed deacylative alkylation of N-acyl 3-substituted indoles using only 1 mol% of Pd(PPh3)4. The scope of this methodology is further defined in the asymmetric synthesis of pyrroloindolines using a diastereoselective approach.

Enantioselective copper-catalyzed construction of aryl pyrroloindolines via an arylation-cyclization cascade

An enantioselective arylation-cyclization cascade has been accomplished using a combination of diaryliodonium salts and asymmetric copper catalysis. These mild catalytic conditions provide a new strategy for the enantioselective construction of pyrroloindolines, an important alkaloid structural motif that is commonly found among biologically active natural products.

Cleavage of alkoxycarbonyl protecting groups from carbamates by t-BuNH2

An efficient, simple protocol for the selective cleavage of a variety of N-alkoxycarbonyl protecting groups by t-BuNH2/MeOH is described. The scope of the procedure was explored for a series of indole, aniline and pyrrolidine carbamate derivatives containing other potentially reactive functional groups affording a clean cleavage of the carbamate group.

Synthesis of indolylmaleimides

The present invention provides a method for synthesizing indolylmaleimides by reacting an activated maleimide preferably with an optionally substituted organometallic-3-indole in the presence of a transition metal catalyst.