1329063-81-1

Basic information

• Product Name: C₂₄H₃₀N₆O₅
• CAS NO: 1329063-81-1
• Molecular Weight: 482.539
• Mol File: 1329063-81-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₂₄H₃₀N₆O₅(CAS DataBase Reference)
• NIST Chemistry Reference: C₂₄H₃₀N₆O₅(1329063-81-1)
• EPA Substance Registry System: C₂₄H₃₀N₆O₅(1329063-81-1)

Safety Data

• Hazardous Substances Data: 1329063-81-1(Hazardous Substances Data)

Upstream product

• 329348-45-0 benzyl (S)-3-{[(tert-butoxy)carbonyl]amino}-4-phenylbutanoate 
• 117142-26-4 (S)-2-tert-butoxycarbonylamino-3-pyridin-3-yl-propionic acid 
• 51871-62-6 (S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid 
• 1329063-43-5 C₄₄H₄₄N₆O₅ 
• 1329063-38-8 (2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalaninyl benzyl ester hydrochloride 
• 1329063-37-7 N-Boc-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine benzyl ester 
• 1329063-33-3 (3S)-β-homophenylalanine benzyl ester hydrochloride 

Downstream Products

• 1329063-23-1 phenylacetyl-aza-glycinyl-(2S)-prolyl-(2S)-3-pyridinylalaninyl-(3S)-β-homophenylalanine 

Relevant articles and documents

Targeting the prostaglandin f2α receptor for preventing preterm labor with azapeptide tocolytics

The prostaglandin-F2α (PGF2α) receptor (FP) was targeted to develop tocolytic agents for inhibiting preterm labor. Azabicycloalkane and azapeptide mimics 2-10 were synthesized based on the (3S,6S,9S)-indolizidin-2- one amino acid analogue PDC113.824 (1), which was shown to modulate FP by a biased allosteric mechanism, involving both Gαq- and Gα12-mediated signaling pathways, and exhibited significant tocolytic activity delaying preterm labor in a mouse model (Goupil; et al.J. Biol. Chem. 2010, 285, 25624-25636). Although changes in azabicycloalkane stereochemistry and ring size caused loss of activity, replacement of the indolizidin-2-one amino acid with azaGly-Pro and azaPhe-Pro gave azapeptides 6 and 8, which reduced PGF2α-induced myometrial contractions, potentiated the effect of PGF2α on Gαq-mediated ERK1/2 activation, and inhibited FP modulation of cell ruffling, a response dependent on the Gα12/RhoA/ROCK signaling pathway. Revealing complementarities of azabicycloalkane and azapeptide mimics, novel probes, and efficient tocolytic agents were made to study allosteric modulation of the FP receptor.