329348-45-0

Upstream product

• 51871-62-6 (S)-3-tert-butoxycarbonylamino-4-phenylbutanoic acid 
• 100-39-0 benzyl bromide 
• 60398-41-6 (3S)-tert-butyl 1-benzyl-3-diazo-2-oxopropylcarbamate 
• 100-51-6 benzyl alcohol 
• 13734-34-4 N-tert-butoxycarbonyl-L-phenylalanine 

Downstream Products

• 140210-06-6 (S)-3-Amino-4-phenyl-butyric acid benzyl ester 
• 1329063-30-0 phenylacetyl-aza-alaninyl-(2S)-prolyl-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine 
• 1329063-32-2 C₄₂H₄₅N₅O₆ 
• 1329063-33-3 (3S)-β-homophenylalanine benzyl ester hydrochloride 
• 1329063-37-7 N-Boc-(2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalanine benzyl ester 
• 1329063-38-8 (2S)-(3-pyridyl)alaninyl-(3S)-β-homophenylalaninyl benzyl ester hydrochloride 
• 1329063-39-9 C₃₉H₄₇N₅O₇ 
• 1329063-41-3 C₃₄H₃₉N₅O₅*ClH 
• 1329063-43-5 C₄₄H₄₄N₆O₅ 
• 634586-78-0 PD⁽³⁸⁾C₁₁₂₄ 
• 1329063-16-2 C₃₃H₄₂N₆O₇ 
• 1329063-70-8 C₄₂H₄₄N₆O₆ 
• 1329063-72-0 C₄₆H₄₈N₆O₆ 
• 1329063-73-1 C₄₂H₄₆N₆O₆ 

Relevant academic research and scientific papers

Targeting the prostaglandin f2α receptor for preventing preterm labor with azapeptide tocolytics

The prostaglandin-F2α (PGF2α) receptor (FP) was targeted to develop tocolytic agents for inhibiting preterm labor. Azabicycloalkane and azapeptide mimics 2-10 were synthesized based on the (3S,6S,9S)-indolizidin-2- one amino acid analogue PDC113.824 (1), which was shown to modulate FP by a biased allosteric mechanism, involving both Gαq- and Gα12-mediated signaling pathways, and exhibited significant tocolytic activity delaying preterm labor in a mouse model (Goupil; et al.J. Biol. Chem. 2010, 285, 25624-25636). Although changes in azabicycloalkane stereochemistry and ring size caused loss of activity, replacement of the indolizidin-2-one amino acid with azaGly-Pro and azaPhe-Pro gave azapeptides 6 and 8, which reduced PGF2α-induced myometrial contractions, potentiated the effect of PGF2α on Gαq-mediated ERK1/2 activation, and inhibited FP modulation of cell ruffling, a response dependent on the Gα12/RhoA/ROCK signaling pathway. Revealing complementarities of azabicycloalkane and azapeptide mimics, novel probes, and efficient tocolytic agents were made to study allosteric modulation of the FP receptor.

Syntheses and CD-spectroscopic investigations of longer-chain β-peptides: Preparation by solid-phase couplings of single amino acids, dipeptides, and tripeptides

The synthesis and CD-spectroscopic analysis of eleven water-soluble β-peptides composed of all-β3 or alternating β2- and β3-amino acids is described. Different approaches for the efficient syntheses of longer-chain β-pepti

Solid-phase synthesis of a β-dodecapeptide with seven functionalized side chains and CD-spectroscopic evidence for a dramatic structural switch when going from water to methanol solution

An all-β3-dodecapeptide with a protected N-terminal thiol-anchoring group and with seven side chains has been synthesized in multi-mg amounts by the manual solid-phase technique, applying Fmoc methodology and the Wang resin. The sequence is β-H