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GMP factory of top grade Rifampicin
Cas No: 13292-46-1
No Data 1 Kilogram 50 Metric Ton/Year Zhengzhou Yuanli Biological Technology Co., Ltd. Contact Supplier
Rifampicin 0.5 and 0.7 density 99%USP BP
Cas No: 13292-46-1
No Data 1 Gram 5 Metric Ton/Day Hangzhou Dawn Ray Pharmaceutical Co.,Ltd Contact Supplier
Rifampicin Manufacturer/High quality/Best price/In stock
Cas No: 13292-46-1
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
High quality Rifampicin with best price and good quality cas:13292-46-1
Cas No: 13292-46-1
USD $ 100.0-130.0 / Kilogram 1 Kilogram 99999 Kilogram/Year Hangzhou Dingyan Chem Co., Ltd Contact Supplier
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Cas No: 13292-46-1
No Data 1 Gram 1000 Metric Ton/Month Hangzhou JINLAN Pharm-Drugs Technology Co., Ltd Contact Supplier
13292-46-1 Rifampicin
Cas No: 13292-46-1
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
Good quality Rifampicin//13292-46-1
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No Data 1 Kilogram 10 Metric Ton/Month Hefei TNJ chemical industry co.,ltd Contact Supplier
rifampicin
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No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
13292-46-1 RIFAMPICIN in stock
Cas No: 13292-46-1
USD $ 100.0-100.0 / Metric Ton 50 Metric Ton 100 Kilogram/Day Arshine Pharmaceutical Co., Limited Contact Supplier
Bulk Pure Rifampicin Rifampin Powder
Cas No: 13292-46-1
USD $ 1.0-1.0 / Kilogram 1 Kilogram 10 Metric Ton/Month Shaanxi Greenyo Biotech Co., Ltd. Contact Supplier

13292-46-1 Usage

Chemical Properties

Red to Orange Crystalline Solid

Uses

Semisynthetic antibiotic. Antibacerial (tuberculostatic)

Uses

antibacterial (tuberculostatic)

Brand name

Rifadin (Sanofi Aventis); Rimactane (Actavis).

Definition

ChEBI: A member of the class of rifamycins that is a a semisynthetic antibiotic derived from Amycolatopsis rifamycinica (previously known as Amycolatopsis mediterranei and Streptomyces mediterranei)

Purification Methods

This macrolide antibiotic crystallises form Me2CO in red-orange plates. It has UV max at 237, 255, 334, and 475nm ( 33,200, 32,100, 27,000 and 15,400) at pH 7.38. It is stable in Me2SO and H2O and is freely soluble in most organic solvents but slightly soluble in H2O at pH <6. [Binda et al. Arzneim.-Forsch 21 1907 1971.] It inhibits cellular RNA synthesis without affecting DNA [Calvori et al. Nature 207 417 1965].
InChI:InChI=1/C43H58N4O12/c1-21-12-11-13-22(2)42(55)45-33-28(20-44-47-17-15-46(9)16-18-47)37(52)30-31(38(33)53)36(51)26(6)40-32(30)41(54)43(8,59-40)57-19-14-29(56-10)23(3)39(58-27(7)48)25(5)35(50)24(4)34(21)49/h11-14,19-21,23-25,29,34-35,39,49-53H,15-18H2,1-10H3,(H,45,55)/b12-11+,19-14+,22-13-,44-20?/t21?,23-,24-,25-,29+,34+,35-,39+,43+/m1/s1

13292-46-1 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
TCI America (R0079)  Rifampicin  >98.0%(T) 13292-46-1 25g 780.00CNY Detail
TCI America (R0079)  Rifampicin  >98.0%(T) 13292-46-1 5g 240.00CNY Detail

13292-46-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 10, 2017

Revision Date: Aug 10, 2017

1.Identification

1.1 GHS Product identifier

Product name rifampicin

1.2 Other means of identification

Product number -
Other names rifobac

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:13292-46-1 SDS

13292-46-1Synthetic route

N-amino-N'-methylpiperazine
6928-85-4

N-amino-N'-methylpiperazine

N-tert-1,3-oxazine(5,6-c)rifamycin

N-tert-1,3-oxazine(5,6-c)rifamycin

rifampicin
13292-46-1

rifampicin

Conditions
ConditionsYield
With acetic acid In butan-1-ol at 70℃; for 2h; Temperature; Solvent; Large scale;97.87%
In water; N,N-dimethyl-formamide at 75℃; for 0.333333h; Temperature; Time;92%
In N,N-dimethyl-formamide at 80℃; for 0.333333h; Concentration;
N-amino-N'-methylpiperazine
6928-85-4

N-amino-N'-methylpiperazine

(PhCH2)(p-(rifamycin SV-3-yl-CH=NNHCH2)C6H4CH2)N-PEGA 1900 resin

(PhCH2)(p-(rifamycin SV-3-yl-CH=NNHCH2)C6H4CH2)N-PEGA 1900 resin

rifampicin
13292-46-1

rifampicin

Conditions
ConditionsYield
With hydrogenchloride In tetrahydrofuran at 20℃; for 24h;18 mg
pyrrolidine
123-75-1

pyrrolidine

N-amino-N'-methylpiperazine
6928-85-4

N-amino-N'-methylpiperazine

di(isobutoxymethyl)-methylamine

di(isobutoxymethyl)-methylamine

rifampicin
13292-46-1

rifampicin

Conditions
ConditionsYield
With acetic acid In water; dimethyl sulfoxide; acetone
Conditions
ConditionsYield
In N-methyl-acetamide; water
N-amino-N'-methylpiperazine
6928-85-4

N-amino-N'-methylpiperazine

1,3,5-tri-tert-butyl-1,3,5-triazacyclohexane
10560-39-1

1,3,5-tri-tert-butyl-1,3,5-triazacyclohexane

rifampicin
13292-46-1

rifampicin

Conditions
ConditionsYield
With acetic acid In N-methyl-acetamide
N-amino-N'-methylpiperazine
6928-85-4

N-amino-N'-methylpiperazine

1,3,5-tris[2-(morpholin-4-yl)ethyl][1,3,5]triazinane
70935-97-6

1,3,5-tris[2-(morpholin-4-yl)ethyl][1,3,5]triazinane

rifampicin
13292-46-1

rifampicin

Conditions
ConditionsYield
With nitrogen; oxalic acid In N-methyl-acetamide; dichloromethane
oxalic acid In ISOPROPYLAMIDE
Conditions
ConditionsYield
With oxalic acid; paraformaldehyde In N-methyl-acetamide
Conditions
ConditionsYield
With oxalic acid; paraformaldehyde In N-methyl-acetamide
1,3,5-tri-tert-butyl-1,3,5-triazacyclohexane
10560-39-1

1,3,5-tri-tert-butyl-1,3,5-triazacyclohexane

rifampicin
13292-46-1

rifampicin

Conditions
ConditionsYield
In N-methyl-acetamide
With paraformaldehyde In dimethyl sulfoxide
C59H66Cl4N5O16Pol

C59H66Cl4N5O16Pol

A

C17H9Cl4F3NO4Pol

C17H9Cl4F3NO4Pol

B

rifampicin
13292-46-1

rifampicin

Conditions
ConditionsYield
With trifluoroacetic acid polystyrene ((aminomethyl)polystyrene); Product distribution / selectivity;
C77H112N4O15

C77H112N4O15

A

C34H56O4

C34H56O4

B

rifampicin
13292-46-1

rifampicin

Conditions
ConditionsYield
With water In tetrahydrofuran; aq. phosphate buffer at 4℃; for 192h; pH=7.4; Temperature; Reagent/catalyst;
rifampicin
13292-46-1

rifampicin

3-formylrifamycin SV
13292-22-3

3-formylrifamycin SV

Conditions
ConditionsYield
With hydrogenchloride In diethyl ether; water at 20℃; for 96h;88.9%
C54H64N16O24S4(4-)*4Na(1+)

C54H64N16O24S4(4-)*4Na(1+)

rifampicin
13292-46-1

rifampicin

C43H58N4O12*C54H64N16O24S4(4-)*4Na(1+)

C43H58N4O12*C54H64N16O24S4(4-)*4Na(1+)

Conditions
ConditionsYield
for 0.5h; Time;66.7%
5-bromo(2-nitroso)pyridine
1033757-04-8

5-bromo(2-nitroso)pyridine

rifampicin
13292-46-1

rifampicin

C48H59BrN6O13

C48H59BrN6O13

Conditions
ConditionsYield
In tetrahydrofuran at 20℃; for 3h;25%
rifampicin
13292-46-1

rifampicin

rifampicin quinone

rifampicin quinone

Conditions
ConditionsYield
With dihydrogen peroxide; horseradish peroxidase In phosphate buffer at 25℃; pH=5.4; Kinetics; Further Variations:; Reagents; concentrations;
rifampicin
13292-46-1

rifampicin

β‐cyclodextrin
7585-39-9

β‐cyclodextrin

rifampicin β-cyclodextrin complex

rifampicin β-cyclodextrin complex

Conditions
ConditionsYield
In water at 37℃; for 48h; Darkness;
ethylene glycol
107-21-1

ethylene glycol

rifampicin
13292-46-1

rifampicin

2.9C2H6O2*C43H58N4O12*2.8H2O

2.9C2H6O2*C43H58N4O12*2.8H2O

Conditions
ConditionsYield
With water In acetone at 4 - 20℃; for 168h;
rifampicin
13292-46-1

rifampicin

C46H58N2O12
1408300-70-8

C46H58N2O12

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
3: sodium cyanoborohydride / dichloromethane; ethanol / 0.02 h / 20 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C46H57FN2O12
1408300-71-9

C46H57FN2O12

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
3: sodium cyanoborohydride / dichloromethane; ethanol / 0.02 h / 20 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C46H57FN2O12
1408300-72-0

C46H57FN2O12

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
3: sodium cyanoborohydride / dichloromethane; ethanol / 0.02 h / 20 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C46H57FN2O12
1408300-73-1

C46H57FN2O12

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
3: sodium cyanoborohydride / dichloromethane; ethanol / 0.02 h / 20 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C45H54N2O12
55686-24-3

C45H54N2O12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
View Scheme
rifampicin
13292-46-1

rifampicin

3-(benzylamino-methyl)-rifamycin
63624-40-8

3-(benzylamino-methyl)-rifamycin

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
3: sodium cyanoborohydride / dichloromethane; ethanol / 0.02 h / 20 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C45H53FN2O12

C45H53FN2O12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C45H53FN2O12

C45H53FN2O12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C45H53FN2O12

C45H53FN2O12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C45H53ClN2O12

C45H53ClN2O12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C45H53ClN2O12

C45H53ClN2O12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C45H53ClN2O12

C45H53ClN2O12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
View Scheme
rifampicin
13292-46-1

rifampicin

C46H56N2O12

C46H56N2O12

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: hydrogenchloride / water; diethyl ether / 96 h / 20 °C
2: hydrogenchloride / dichloromethane; ethanol / 0.5 h / 45 °C
View Scheme

13292-46-1Upstream product

13292-46-1Downstream Products

13292-46-1Related news

Attainment of target Rifampicin (cas 13292-46-1) concentrations in cerebrospinal fluid during treatment of tuberculous meningitis07/19/2019

ObjectiveThere is considerable uncertainty regarding the optimal use of rifampicin for the treatment of tuberculous (TB) meningitis. A pharmacokinetic modeling and simulation study of rifampicin concentrations in cerebrospinal fluid (CSF) during TB meningitis treatment was performed in this study.detailed

Evolution of Rifampicin (cas 13292-46-1) treatment for tuberculosis07/17/2019

Rifampicin was discovered in 1965 and remains one of the most important drugs in tuberculosis treatment that is valued for its sterilizing activity and ability to shorten treatment. Antimicrobial activity of rifampicin was initially proved in vitro; subsequently numerous in vivo studies showed t...detailed

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