132927-09-4

Basic information

• Product Name: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE;4-Formyl-3-methoxybenzotrifluoride, 2-Formyl-5-(trifluoromethyl)anisole, 4-(Trifluoromethyl)-o-anisaldehyde;2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE, 97%+;2-Methoxy-4-(trifluoromethyl)benzaldehyde99%
• CAS NO: 132927-09-4
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.15
• Mol File: 132927-09-4.mol
• Article Data: 7

Chemical Properties

• Melting Point: 51-55℃
• Boiling Point: 247℃
• Flash Point: 100℃
• Appearance: /
• Density: 1.287
• Vapor Pressure: 0.0268mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE(132927-09-4)
• EPA Substance Registry System: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE(132927-09-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 132927-09-4(Hazardous Substances Data)

Usage

General Description

2-Methoxy-4-(trifluoromethyl)benzaldehyde is a chemical compound with the molecular formula C9H7F3O2. It is a pale yellow liquid with a strong aroma and is commonly used in the production of pharmaceuticals, perfumes, and other organic compounds. This chemical is a key intermediate in the synthesis of various pharmaceuticals, agrochemicals, and other fine chemicals due to its versatile nature and highly reactive properties. It is also used as a flavoring agent in the food industry and as an intermediate in the production of organic dyes and pigments. Additionally, it is employed in the research and development of new materials and as a reagent in organic synthesis.

InChI:InChI=1/C9H7F3O2/c1-14-8-4-7(9(10,11)12)3-2-6(8)5-13/h2-5H,1H3

Upstream product

• 454-90-0 3-(trifluoromethyl)anisole 
• 68-12-2 N,N-dimethyl-formamide 
• 58914-34-4 2-hydroxy-4-(trifluoromethyl)benzaldehyde 
• 74-88-4 methyl iodide 
• 286441-68-7 2-methoxy-4-(trifluoromethyl)benzyl alcohol 
• 286441-66-5 methyl 2-methoxy-4-(trifluoromethyl)benzoate 
• 220162-64-1 methyl 2-fluoro-4-(trifluoromethyl)benzoate 
• 132927-08-3 2-methoxy-4-trifluoromethyl-benzonitrile 
• 100-46-9 benzylamine 
• 124-41-4 sodium methylate 
• 89763-93-9 2-Fluoro-4-(trifluoromethyl)benzaldehyde 

Downstream Products

• 1025953-97-2 (2E,4E)-5-(2-Methoxy-4-trifluoromethyl-phenyl)-penta-2,4-dienal 
• 1025993-04-7 (2E,4E)-5-(2-Methoxy-4-trifluoromethyl-phenyl)-penta-2,4-dien-1-ol 
• 58914-34-4 2-hydroxy-4-(trifluoromethyl)benzaldehyde 

Relevant articles and documents

Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation

A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.

SUBSTITUTED ACIDS FOR THE TREATMENT OF RESPIRATORY DISEASES

The invention relates to substituted acids of formula (I), where T,W,X,Y,Z, R1 and R2 as defined in the claims, as useful pharmaceutical compounds for treating asthma and rhinitis, pharmaceutical compositions containing them, and a processes for their preparation.

Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11 - 13 under acidic conditions afforded a series of dioxane-triazole compounds 14 - 16. The antifungal activities of the compounds 14 - 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond(s) and an aromatic ring substituted with an electron-withdrawing group in the side chain. Among the derivatives, R-102557 (16R: Ar=4-(2,2,3,3- tetrafluoropropoxy)phenyl) showed excellent in vivo activities against Candida, Aspergillus and Cryptococcus species. It also showed high tolerance in a preliminary toxicity study in rats.