132927-09-4

Basic information

• Product Name: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE
• Synonyms: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE;4-Formyl-3-methoxybenzotrifluoride, 2-Formyl-5-(trifluoromethyl)anisole, 4-(Trifluoromethyl)-o-anisaldehyde;2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE, 97%+;2-Methoxy-4-(trifluoromethyl)benzaldehyde99%
• CAS NO: 132927-09-4
• Molecular Formula: C₉H₇F₃O₂
• Molecular Weight: 204.15
• Mol File: 132927-09-4.mol

Chemical Properties

• Melting Point: 51-55℃
• Boiling Point: 247℃
• Flash Point: 100℃
• Appearance: /
• Density: 1.287
• Vapor Pressure: 0.0268mmHg at 25°C
• Refractive Index: 1.475
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Sensitive: Air Sensitive
• CAS DataBase Reference: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE(132927-09-4)
• EPA Substance Registry System: 2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE(132927-09-4)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 132927-09-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
2-Methoxy-4-(trifluoromethyl)benzaldehyde is utilized as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure and reactivity make it suitable for the development of new drugs with potential therapeutic applications.
Used in Perfume Industry:
2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE is employed as a flavoring agent in the perfume industry, where its strong aroma contributes to the creation of various fragrances.
Used in Agrochemical Industry:
2-Methoxy-4-(trifluoromethyl)benzaldehyde is used in the production of agrochemicals, serving as an intermediate in the synthesis of compounds that can be used in agriculture for pest control and crop protection.
Used in Food Industry:
As a flavoring agent, 2-Methoxy-4-(trifluoromethyl)benzaldehyde is used in the food industry to enhance the taste and aroma of various food products.
Used in Organic Dyes and Pigments Production:
2-METHOXY-4-(TRIFLUOROMETHYL)BENZALDEHYDE is utilized as an intermediate in the production of organic dyes and pigments, contributing to the development of colorants for various applications, including textiles, plastics, and printing inks.
Used in Research and Development:
2-Methoxy-4-(trifluoromethyl)benzaldehyde is employed in research and development for the exploration of new materials and the advancement of organic synthesis techniques, further expanding its applications across different industries.

InChI:InChI=1/C9H7F3O2/c1-14-8-4-7(9(10,11)12)3-2-6(8)5-13/h2-5H,1H3

Upstream product

• 124-41-4 sodium methylate 
• 89763-93-9 2-Fluoro-4-(trifluoromethyl)benzaldehyde 
• 454-90-0 3-(trifluoromethyl)anisole 
• 68-12-2 N,N-dimethyl-formamide 
• 58914-34-4 2-hydroxy-4-(trifluoromethyl)benzaldehyde 
• 74-88-4 methyl iodide 
• 132927-08-3 2-methoxy-4-trifluoromethyl-benzonitrile 
• 100-46-9 benzylamine 
• 286441-66-5 methyl 2-methoxy-4-(trifluoromethyl)benzoate 
• 220162-64-1 methyl 2-fluoro-4-(trifluoromethyl)benzoate 
• 286441-68-7 2-methoxy-4-(trifluoromethyl)benzyl alcohol 

Downstream Products

• 1026230-08-9 (2E,4E)-5-(2-Methoxy-4-trifluoromethyl-phenyl)-penta-2,4-dienoic acid ethyl ester 
• 1027888-79-4 2-methoxy-4-(trifluoromethyl)phenol 

Relevant articles and documents

Regioselective formylation of 1,3-disubstituted benzenes through in situ lithiation

A facile method of regioselective formylation of disubstituted benzene via in situ deprotonation/metalation using n-BuLi/TMEDA/DIPA has been developed. Effect of different electron withdrawing and electron donating substituents in 1,3-interrelated aromatic system was studied; the metalation mostly occurred at the 2-position to afford the desired products in high yields.

6-SUBSTITUTED PHENOXYCHROMAN CARBOXYLIC ACID DERIVATIVES

Compounds of Formula (I): in which A1, A2, W, L, G, R7a, R7b, R8, R9 and R10 have the meanings given in the specification, are DP2 receptor modulators useful in the treatment of immunologic diseases.

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CARBOXYLIC ACID DERIVATIVES AND DRUGS CONTAINING THE SAME

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Synthesis and antifungal activities of R-102557 and related dioxane- triazole derivatives

Novel triazole compounds with a dioxane ring were synthesized. Condensation of the diol precursor 10 with various aromatic aldehydes 11 - 13 under acidic conditions afforded a series of dioxane-triazole compounds 14 - 16. The antifungal activities of the compounds 14 - 16 were evaluated in vivo in mice infection models against Candida and Aspergillus species. High activities were seen for the derivatives with one or two double bond(s) and an aromatic ring substituted with an electron-withdrawing group in the side chain. Among the derivatives, R-102557 (16R: Ar=4-(2,2,3,3- tetrafluoropropoxy)phenyl) showed excellent in vivo activities against Candida, Aspergillus and Cryptococcus species. It also showed high tolerance in a preliminary toxicity study in rats.

Arthropodicidal pyrazolines, pyrazolidines and hydrazines

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