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Usage

Uses

Used in Pharmaceutical Industry:
2-Fluoro-4-(trifluoromethyl)benzaldehyde is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable building block for the development of new drugs with improved therapeutic properties.
Used in Chemical Synthesis:
In the field of organic chemistry, 2-Fluoro-4-(trifluoromethyl)benzaldehyde is used as a versatile starting material for the synthesis of a wide range of organic compounds. Its reactivity allows for various chemical reactions, such as condensation, reduction, and substitution, enabling the formation of diverse chemical entities.
Used in the Synthesis of Methyl 3-amino-6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate:
2-Fluoro-4-(trifluoromethyl)benzaldehyde is specifically used in the synthesis of methyl 3-amino-6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate, a compound with potential applications in various industries. This synthesis showcases the compound's utility in creating complex and functionalized molecules for further use.

InChI:InChI=1/C20H17F17O6/c1-3-41-9(38)7-12(10(39)42-4-2)5-8(43-11(12)40)6-13(21,22)14(23,24)15(25,26)16(27,28)17(29,30)18(31,32)19(33,34)20(35,36)37/h8H,3-7H2,1-2H3

Upstream product

• 197239-49-9 2-fluoro-4-(trifluoromethyl)benzyl alcohol 
• 455-19-6 4-Trifluoromethylbenzaldehyde 

Downstream Products

• 1026956-43-3 (E)-3-(2-Fluoro-4-trifluoromethyl-phenyl)-acrylic acid ethyl ester 
• 719277-18-6 N-butyl-N-[2-fluoro-4-(trifluoromethyl)benzyl]amine 
• 262608-88-8 3-(2-fluoro-4-trifluoromethyl-phenyl)-acrylic acid 
• 132927-09-4 2-methoxy-4-(trifluoromethyl)benzaldehyde 
• 873194-08-2 3-[2-formyl-5-(trifluoromethyl)phenoxy]benzonitrile 
• 204707-33-5 α-(2-fluoro-4-trifluoromethylphenyl)-N-t-butylnitrone 
• 1194283-42-5 2-(3,4-dihydroisoquinolin-2(1H)-yl)-4-(trifluoromethyl)benzaldehyde 
• 1194283-43-6 C₁₉H₁₈F₃NO₃ 
• 197239-49-9 2-fluoro-4-(trifluoromethyl)benzyl alcohol 
• 1132650-51-1 ethyl 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylate 
• 1261266-24-3 (2E,5E)-2,5-bis(2-fluoro-4-(trifluoromethyl)benzylidene)cyclopentanone 
• 142329-22-4 6-(trifluoromethyl)benzo[b]thiophene-2-carboxylic acid 
• 1383611-96-8 2-(tert-butylthio)-4-(trifluoromethyl)benzaldehyde 

Relevant academic research and scientific papers

Elemental fluorine. Part 21. (1) direct fluorination of benzaldehyde derivatives

Direct fluorination of a range of benzaldehyde derivatives gives mixtures of fluorobenzaldehyde and benzoyl fluoride products in ratios that depend upon the nature of the ring substituent Electron-withdrawing substituents give predominantly benzoyl fluoride derivatives, whereas electron-donating substituents lead to fluoroarene systems. Separation of ring-fluorinated products can be easily accomplished by esterification of the benzoyl fluoride side products. Scale-up of these processes to provide significant quantities of appropriate fluorobenzaldehyde systems has also been achieved using continuous flow techniques.

Vanilloid receptor ligands and their use in treatments

Compounds having the general structure and compositions containing them, for the treatment of acute, inflammatory and neuropathic pain, dental pain, general headache, migraine, cluster headache, mixed-vascular and non-vascular syndromes, tension headache, general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, inflammatory pain and associated hyperalgesia and allodynia, neuropathic pain and associated hyperalgesia and allodynia, diabetic neuropathy pain, causalgia, sympathetically maintained pain, deafferentation syndromes, asthma, epithelial tissue damage or dysfunction, herpes simplex, disturbances of visceral motility at respiratory, genitourinary, gastrointestinal or vascular regions, wounds, burns, allergic skin reactions, pruritis, vitiligo, general gastrointestinal disorders, gastric ulceration, duodenal ulcers, diarrhea, gastric lesions induced by necrotising agents, hair growth, vasomotor or allergic rhinitis, bronchial disorders or bladder disorders.