13294-42-3

Upstream product

• 71-43-2 benzene 
• 1006-41-3 2-bromo-4-fluorobenzoic acid 
• 229027-89-8 (2-bromo-4-fluorophenyl)methanol 
• 59142-68-6 2-bromo-4-fluorobenzaldehyde 
• 100-58-3 phenylmagnesium bromide 
• 60081-01-8 2-bromo-4-fluorobenzhydrol 
• 95383-36-1 2-bromo-4-fluorobenzoyl chloride 

Relevant academic research and scientific papers

Synthesis of 9-substituted fluorenols and heteroring-fused analogues by intramolecular ch functionalization

A method for the selective synthesis of 9-substituted fluorenols (FOLs) was developed by suppressing intermolecular cyclization and promoting intramolecular CH functionalization. This protocol was applied to the synthesis of heteroring-fused FOLs. Further, the obtained FOLs were converted to fulvenes by dehydration.

Visible Light Photocatalytic Radical Addition/Cyclization Reaction of o-Vinyl-N-Alkoxybenzamides for Synthesis of CF3-Containing Iminoisobenzofurans

A visible light-induced photocatalytic radical addition/cyclization reaction of o-vinyl-N-alkoxybenzamides has been accomplished for efficient synthesis of diversely functionalized CF3-containing iminoisobenzofurans. This external oxidant-free and mild protocol features ready availability of starting materials, excellent regioselectivity, good substrate scope and functional group tolerance. (Figure presented.).

Synthesis of Substituted Naphthalenes by 1,4-Palladium Migration Involved Annulation with Internal Alkynes

The palladium catalyzed annulation of 1-bromo-2-vinylbenzene derivatives with internal alkynes was realized for the efficient synthesis of substituted naphthalenes. A controllable aryl to vinylic 1,4-palladium migration process is the key for success.

Synthesis of structurally diverse diarylketones through the diarylmethyl sp3 C-H oxidation

Under open-flask conditions, an efficient method to assemble a series of diversely functionalized diarylketones in the presence of commercially available NBS has been developed. Yields of up to 99% have been achieved employing diarylmethanes as starting material. Based on 18O-labeled experiment, the addition of stoichiometric water eventually leads to excellent yields in all carbonylation cases.

One-pot synthesis of 4-methylisoquinolines via a sequential Pd-catalyzed Heck reaction and intramolecular cyclization

An efficient, one-pot synthesis of 4-methylisoquinolines via a cascade Pd-catalyzed Heck reaction, intramolecular cyclization and isomerization has been developed. This reaction has a wide range of substrates with various functional groups, and the corresponding products have been obtained in good yields.