132940-42-2Relevant academic research and scientific papers
Xanthine derivatives
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, (2008/06/13)
The present invention relates to novel xanthine derivatives of the formula (I) which are selectively antagonistic to an adenosine A 2 receptor, and pharmaceutically acceptable salts thereof. Formula (I): STR1 In the formula, R 1 and R 2 are the same or di
Adenosine A(2A) antagonists with potent anti-cataleptic activity
Shimada, Junichi,Koike, Nobuaki,Nonaka, Hiromi,Shiozaki, Shizuo,Yanagawa, Koji,Kanda, Tomoyuki,Kobayashi, Hiroyuki,Ichimura, Michio,Nakamura, Joji,Kase, Hiroshi,Suzuki, Fumio
, p. 2349 - 2352 (2007/10/03)
Structure-activity relationships of 8-styrylxanthines for in vivo adenosine A(2A) antagonism were explored. Diethyl substitution both at the 1- and S-position was found to dramatically potentiate the anti-cataleptic activity.
Structure-activity relationships of 8-styrylxanthines as A2-selective adenosine antagonists
Jacobson,Gallo-Rodriguez,Melman,Fischer,Maillard,Van Bergen,Van Galen,Karton
, p. 1333 - 1342 (2007/10/02)
A series of substituted 8-styryl derivatives of 1,3,7-alkylxanthines was synthesized as potential A2-selective adenosine receptor antagonists, and the potency at rat brain A1- and A2-receptors was studied in radioligand bi
1,3,8-Trisubstituted xanthines. Effect of substitution pattern upon adenosine receptor A1/A2 affinity
Erickson, Ronald H.,Hiner, Roger N.,Feeney, Scott W.,Blake, Paul R.,Rzeszotarski, Waclaw J.,et al.
, p. 1431 - 1435 (2007/10/02)
A series of 11,8-substituted xanthines having three different substitution patterns on the 1- and 3-positions was prepared.These compounds were assessed for
