1329671-76-2

Upstream product

• 1329671-73-9 4-(8-(3,4-difluorophenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-ylamino)-1-(6-methylpyrimidin-4-yl)piperidine-4-carbonitrile 
• 75-16-1 methylmagnesium bromide 
• 1329672-73-2 8-(6-methylpyrimidin-4-yl)-1,4-dioxa-8-azaspiro[4.5]decane 
• 3435-25-4 4-methyl-6-chloropyrimidine 
• 177-11-7 4,4-ethylenedioxy-piperidine 

Relevant academic research and scientific papers

HETEROARYL SUBSTITUTED PIPERIDINES

The invention relates to compounds of formula where hetaryl I, hetaryl II, R1,R2,R3, R4, m, n, and o are as defined in the specification or to pharmaceutically active acid addition salts thereof. The compounds of formula I are modulators for amyloid beta and thus may be useful for the treatment or prevention of a disease associated with the deposition of β-amyloid in the brain, in particular Alzheimer's disease, and other diseases such as cerebral amyloid angiopathy, hereditary cerebral hemorrhage with amyloidosis, Dutch-type (HCHWA-D), multi-infarct dementia, dementia pugilistica and Down syndrome.