1329682-30-5

Upstream product

• 7703-74-4 2,6-bis-(bromomethyl)pyridine 
• 74571-94-1 (2R)-2-(benzylamino)-3-methylbutan-1-ol 
• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 640-68-6 D-Val-OH 
• 1133706-09-8 (E)-(R)-(+)-N-(2-hydroxy-1-isopropylethyl)benzylideneamine 

Downstream Products

• 1329682-34-9 (5R,15R)-6,14-dibenzyl-5,15-bis(propan-2-yl)-3,17-dioxa-6,14,23,24-tetraazatricyclo[17.3.1.1(8,12)]tetracosa-1⁽²³⁾,8,10,12⁽²⁴⁾,19,21-hexaene 

Relevant academic research and scientific papers

Pyridine containing chiral macrocycles: Synthesis and their enantiomeric recognition for amino acid derivatives

Four novel C2-symmetric enantiomerically pure, chiral pyridine-18-crown-6 type macrocycles containing lipophilic chains at the stereogenic centers were prepared. The enantioselectivity of the new ligands toward the enantiomers of d-,l-amino acid methyl ester derivatives were also determined by 1H NMR titration method. These novel macrocycles have been showed to be strong complexing agents for d- and l-amino acid methyl ester hydrochloride salts (with Kass up to 13590 M-1 and G 0 up to 23.3 kJ mol-1 and selectivity ratio: 80:20) by 1H NMR titration methods. These macrocyclic hosts exhibited enantioselective binding towards the d-enantiomer of valine methyl ester hydrochloride with Kd/Kl up to 5.08 in CDCl3 with 0.25% CD3OD.