74571-94-1

Upstream product

• 4276-09-9 (R)-2-amino-3-methylbutanol 
• 100-39-0 benzyl bromide 
• 1133706-09-8 (E)-(R)-(+)-N-(2-hydroxy-1-isopropylethyl)benzylideneamine 
• 640-68-6 D-Val-OH 

Downstream Products

• 1329682-30-5 (2R)-2-{benzyl[(6-[[benzyl-(2R)-(1-hydroxy-3-methylbutan-2-yl)amino]methyl]pyridin-2-yl)methyl]amino}-3-methylbutan-1-ol 
• 1329682-34-9 (5R,15R)-6,14-dibenzyl-5,15-bis(propan-2-yl)-3,17-dioxa-6,14,23,24-tetraazatricyclo[17.3.1.1(8,12)]tetracosa-1⁽²³⁾,8,10,12⁽²⁴⁾,19,21-hexaene 
• 123054-24-0 Boc-PheΨ(R)Val-Phe-OMe 
• 123122-71-4 (1'R,2S,3S)-N², N², N³-tribenzyl-N³-<1'-9hydroxymethyl)-2'-methylpropyl>-1-phenyl-2,3-pentanediamine 
• 123054-19-3 [(1S,2S)-1-Benzyl-2-((R)-1-hydroxymethyl-2-methyl-propylamino)-butyl]-carbamic acid tert-butyl ester 
• 74571-99-6 (R)-4-Benzyl-3-isopropyl-morpholine 
• 123054-04-6 (1'S,2RS,4R)-3-benzyl-2-<1'-(dibenzylamino)-2'-phenylethyl>-4-(methylethyl)-1,3-oxazolidine 
• 74571-96-3 (R)-2-[Benzyl-(2-hydroxy-ethyl)-amino]-3-methyl-butan-1-ol 

Relevant academic research and scientific papers

FUSED TRICYCLIC PYRAZOLO-DIHYDROPYRAZINYL-PYRIDONE COMPOUNDS AS ANTIVIRALS

The invention provides compounds of Formula (I) as described herein, along with pharmaceutically acceptable salts, pharmaceutical compositions and pharmaceutical combinations containing such compounds, as well as methods to use these compounds, salts and compositions for treating viral infections, particularly infections caused by hepatitis B virus (HBV), and for reducing the occurrence of serious conditions associated with HBV.

Pyridine containing chiral macrocycles: Synthesis and their enantiomeric recognition for amino acid derivatives

Four novel C2-symmetric enantiomerically pure, chiral pyridine-18-crown-6 type macrocycles containing lipophilic chains at the stereogenic centers were prepared. The enantioselectivity of the new ligands toward the enantiomers of d-,l-amino acid methyl ester derivatives were also determined by 1H NMR titration method. These novel macrocycles have been showed to be strong complexing agents for d- and l-amino acid methyl ester hydrochloride salts (with Kass up to 13590 M-1 and G 0 up to 23.3 kJ mol-1 and selectivity ratio: 80:20) by 1H NMR titration methods. These macrocyclic hosts exhibited enantioselective binding towards the d-enantiomer of valine methyl ester hydrochloride with Kd/Kl up to 5.08 in CDCl3 with 0.25% CD3OD.