1329683-01-3Relevant academic research and scientific papers
2-[(1E,3E)-4-Arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as Dienes in Diels–Alder Reactions – Experimental and Computational Studies
Albuquerque, Hélio M. T.,Santos, Clementina M. M.,Lima, Carlos F. R. A. C.,Santos, Luís M. N. B. F.,Cavaleiro, José A. S.,Silva, Artur M. S.
, p. 87 - 101 (2017)
The synthesis and reactivity of 2-[(1E,3E)-4-arylbuta-1,3-dien-1-yl]-4H-chromen-4-ones as dienes in Diels–Alder (DA) reactions with several electron-poor and electron-rich dienophiles under microwave irradiation was studied. The optimized reaction conditions were achieved with N-methylmaleimide as the dienophile and Sc(OTf)3(OTf = triflate) as a Lewis acid under microwave-assisted and solvent-free conditions. The Lewis acid improved the reaction yields as it prevented the adducts obtained from undergoing a second DA reaction; thus, the formation of a bisadduct was avoided. The α,β:γ,δ-diene of the starting chromones was the most reactive, and the computational results confirmed the experimental findings. Theoretical calculations also provided a rationale for the unexpected lack of reactivity shown by some dienophiles. The adducts prepared were dehydrogenated with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ); however, the aza adducts were sensitive to the highly energetic reaction conditions necessary for the aromatization.
Synthesis of novel 1-aryl-9 H -xanthen-9-ones
Esteves, Cátia I. C.,Santos, Clementina M. M.,Brito, Cristela M.,Silva, Artur M. S.,Cavaleiro, José A. S.
, p. 1403 - 1406 (2011/08/03)
A novel route for the synthesis of 1-aryl-9H-xanthen-9-ones is reported. This methodology involves the condensation of 2-methylchromone with cinnamaldehydes leading to (E,E)-2-(4-arylbuta-1,3-dien-1-yl)-4H-chromen-4-ones. The final steps involved electrocyclization and oxidation of the latter compounds, in an one-pot synthesis, giving the desired 1-aryl-9H-xanthen-9-ones. Georg Thieme Verlag Stuttgart - New York.
