496035-49-5Relevant academic research and scientific papers
A second-generation total synthesis of (+)-discodermolide: The development of a practical route using solely substrate-based stereocontrol
Paterson, Ian,Delgado, Oscar,Florence, Gordon J.,Lyothier, Isabelle,O'Brien, Matthew,Scott, Jeremy P.,Sereinig, Natascha
, p. 150 - 160 (2007/10/03)
(Chemical Equation Presented). A novel total synthesis of the complex polyketide (+)-discodermolide, a promising anticancer agent of sponge origin, has been completed in 7.8% overall yield over 24 linear steps, with 35 steps altogether. This second-genera
SYNTHESIS OF DISCODERMOLIDE
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Page 75, (2010/11/30)
The invention relates to a process for preparing discodermolide, for preparing intermediates for the manufacture of discodermolide and discodermolide analogues and to the intermediates obtained during the process. Wherein the process proceeds via a tetrae
1,6-asymmetric induction in boron-mediated aldol reactions: application to a practical total synthesis of (+)-discodermolide.
Paterson, Ian,Delgado, Oscar,Florence, Gordon J,Lyothier, Isabelle,Scott, Jeremy P,Sereinig, Natascha
, p. 35 - 38 (2007/10/03)
By relying solely on substrate-based stereocontrol, a practical total synthesis of the microtubule-stabilizing anticancer agent (+)-discodermolide has been realized. This exploits a novel aldol bond construction with 1,6-stereoinduction from the boron eno
Expeditious synthesis of a key C9-C21 subunit of the aplysiatoxins and oscillatoxins
Walkup,Kane,Boatman Jr.,Cunningham
, p. 7587 - 7590 (2007/10/02)
The C9-C21 portion of the aplysiatoxin/oscillatoxin bluegreen algal metabolites was synthesized as the 9-aldehyde bearing a tert-butyldimethylsilyl ether group on the C11 hydroxyl and a trimethylsilylethoxymethyl ether gro
