132974-85-7

Upstream product

• 207738-33-8 (3SR,5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-3-(phenylseleno)-1-tosyl-pyrrolidin-2-one 
• 132974-83-5 (5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one 
• 132974-84-6 (-)-(5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-1-tosylpyrrolidin-2-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 17342-08-4 (S)-Pyroglutaminol 
• 98-79-3 L-Pyroglutamic acid 
• 74936-93-9 (S)-5-oxopyrrolidine-2-carbonyl chloride 

Downstream Products

• 207738-28-1 (-)-(4S,5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]-1-tosylpyrrolidin-2-one 
• 132974-86-8 (4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-ethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-one 
• 229160-60-5 (-)-(4S,5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-1-tosyl-4-[4-(trimethylsilyl)but-3-ynyl]pyrrolidin-2-one 
• 193264-87-8 (-)-(4S,5S)-1-(tert-butoxycarbonyl)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]pyrrolidin-2-one 
• 207738-34-9 (2SR,4S,5S)-1-(tert-butoxycarbonyl)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]pyrrolidin-2-ol 
• 229160-72-9 (+)-(4S,5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-[2-(2-methyl-1,3-dioxolan-2-yl)ethyl]pyrrolidin-2-one 
• 207738-31-6 (-)-(1S,3aS,6aS)-2-(tert-butoxycarbonyl)-1-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-methyl-1,2,3,3a,6,6a-hexahydrocyclopenta[c]pyrrole 
• 207738-30-5 (1S,3aS,6aS)-2-(tert-butoxycarbonyl)-1-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-methyloctahydrocyclopenta[c]pyrrol-4-ol 
• 207738-29-2 (+)-4-(2S,3S)-(1-(tert-butoxycarbonyl)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-2,3-dihydro-1H-pyrrol-3-yl)butan-2-one 
• 229160-74-1 4-((2S,3S)-1-(tert-butoxycarbonyl)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-5-hydroxy-pyrrolidin-3-yl)butan-2-one 
• 207738-32-7 (-)-methyl (2S,3S,4R)-1-(tert-butoxycarbonyl)-2-{[(tert-butyldiphenylsilyl)-oxy]methyl}-4-isopropenylpyrrolidine-3-acetate 
• 1026719-00-5 (2S,3S,4R)-4-Acetyl-2-(tert-butyl-diphenyl-silanyloxymethyl)-3-methoxycarbonylmethyl-pyrrolidine-1-carboxylic acid tert-butyl ester 
• 229160-64-9 (-)-(2S,3S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-but-3-ynyl-1-tosyl-2,3-dihydro-1H-pyrrole 
• 229160-62-7 (2SR,4S,5S)-5-{[(tert-butyldiphenylsilyl)oxy]methyl}-4-but-3-ynyl-1-tosylpyrrolidin-2-ol 

Relevant academic research and scientific papers

Approaches to a synthesis of α-kainic acid

A formal synthesis of (-)-α-kainic acid was achieved from L- pyroglutamic acid. The C-4 substituent of the pyrrolidine ring was introduced by using a ketyl radical cyclization on an ene carbamate.

A formal synthesis of (-)-α-kainic acid

The formal synthesis of (-)-α-kainic acid was achieved from L-pyroglutamic acid. The C-4 substituent of the pyrrolidine ring was introduced by using a ketyl radical cyclization on an enecarbamate.

A POTENTIAL CARBAPENEM INTERMEDIATE FROML-GLUTAMIC ACID

A novel and diastereoselective entry to the β-lactam nucleus of the carbapenems starting from L-glutamic acid is exemplified by the synthesis of the potential (+)-PS-5 intermediate 13.