133-16-4 Usage
Uses
Used in Anesthetic Applications:
2-DIETHYLAMINOETHYL 4-AMINO-2-CHLORO-BENZOATE is used as a local anesthetic for providing regional anesthesia by infiltration, peripheral and central nerve block, including lumbar and caudal epidural blocks. Its rapid metabolism and short duration of action make it suitable for surgical procedures up to 40 minutes in duration.
Used in Spinal Anesthesia:
2-DIETHYLAMINOETHYL 4-AMINO-2-CHLORO-BENZOATE is used as a preservative-free solution for spinal anesthesia, particularly for procedures with a short duration. Its fast onset and short duration of action make it an ideal choice for such applications.
Used in Maternal and Neonatal Care:
2-DIETHYLAMINOETHYL 4-AMINO-2-CHLORO-BENZOATE is used as a local anesthetic in maternal and neonatal patients, with minimal placental passage due to the lower plasma cholinesterase activity in the maternal epidural space.
Used in Oral Surgery:
2-DIETHYLAMINOETHYL 4-AMINO-2-CHLORO-BENZOATE is used as a local anesthetic, particularly for oral surgery. It has the advantage of constricting blood vessels, reducing bleeding during procedures.
Used in Pharmaceutical Industry:
2-DIETHYLAMINOETHYL 4-AMINO-2-CHLORO-BENZOATE is used as an active pharmaceutical ingredient in the production of local anesthetics, under the brand name Nesacaine (Abraxis).
Biological Functions
Chloroprocaine hydrochloride (Nesacaine) is obtained
from addition of a chlorine atom to procaine, which results
in a compound of greater potency and less toxicity
than procaine itself. This local anesthetic is hydrolyzed
very rapidly by cholinesterase and therefore has a short
plasma half-life. Because it is broken down rapidly,
chloroprocaine is commonly used in obstetrics. It is believed
that the small amount that might get to the fetus
continues to be rapidly hydrolyzed, so there may be no
residual effects on the neonate.
Clinical Use
Chloroprocaine is used for cutaneous or mucous membraneinfiltration for surgical procedures, epidural anesthesia(without preservatives) and for peripheral conduction block.
Check Digit Verification of cas no
The CAS Registry Mumber 133-16-4 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 1,3 and 3 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133-16:
(5*1)+(4*3)+(3*3)+(2*1)+(1*6)=34
34 % 10 = 4
So 133-16-4 is a valid CAS Registry Number.
InChI:InChI=1/C13H19ClN2O2/c1-3-16(4-2)7-8-18-13(17)11-6-5-10(15)9-12(11)14/h5-6,9H,3-4,7-8,15H2,1-2H3
