10367-96-1

Basic information

• Product Name: Benzoic acid, 2-chloro-4-nitro-, 2-(diethylamino)ethyl ester
• CAS NO: 10367-96-1
• Molecular Formula: C13H17ClN2O4
• Molecular Weight: 300.742
• Mol File: 10367-96-1.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 2-chloro-4-nitro-, 2-(diethylamino)ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 2-chloro-4-nitro-, 2-(diethylamino)ethyl ester(10367-96-1)
• EPA Substance Registry System: Benzoic acid, 2-chloro-4-nitro-, 2-(diethylamino)ethyl ester(10367-96-1)

Safety Data

• Hazardous Substances Data: 10367-96-1(Hazardous Substances Data)

Upstream product

• 99-60-5 2-chloro-4-nitrobenzoic acid 
• 100-37-8 2-(Diethylamino)ethanol 
• 73097-02-6 ethyl 2-chloro-4-nitrobenzoate 

Downstream Products

• 133-16-4 chloroprocaine 
• 119342-76-6 2,2'-dichloro-4,4'-azoxy-di-benzoic acid diethyl ester 
• 94-09-7 p-aminoethylbenzoate 
• 13324-11-3 methyl 2-chloro-4-nitrobenzoate 
• 16017-69-9 ethyl-2-chloro-4-amino-benzoate 
• 3858-89-7 chloroprocaine hydrochloride 

Relevant articles and documents

Preparation method of chloroprocaine hydrochloride

The invention belongs to the technical field of organic drug synthesis and particularly relates to a preparation method of chloroprocaine. The preparation method includes the steps that 1, 2-chloro-4-nitrobenzoic acid and 2-diethylaminoethanol reaction raw materials are added into a xylene reaction solvent, para-toluenesulfonic acid or immobilized liquid acid or faintly acid metal salt is added to serve as a catalyst, heating is conducted till reflux is achieved, a reaction is carried out for a certain period of time, aftertreatment is carried out, and a water solution of nitrochlor cain is obtained; 2, ammonium chloride and iron powder are added into the water solution of nitrochlor cain, a heating reaction is carried out, aftertreatment is carried out, and crude chloroprocaine hydrochloride is obtained; refining is carried out, and chloroprocaine hydrochloride is obtained. The direct esterification reaction time is short, the production period is shortened by 30% or above, the total yield of the finished product is larger than 30%, and energy consumption is reduced by 25% or above. The content of chloroprocaine hydrochloride is not smaller than 99.0%, the content of related substances is not larger than 1.0%, and the content of a residual solvent (dimethylbenzene) does not exceed 0.1%. The preparation method is suitable for industrial production.

Immobilised Candida antarctica B as efficient catalyst for the synthesis of local anaesthetic intermediates

We hereby present the development of new reaction conditions for the CALB catalysed esterification of substituted benzoic acids. Using cyclohexane as the reaction media a number of heptyl benzoates have been easily isolated in good to excellent yields (up to 100% at 80 C, 20-24 h). Moreover, the catalytic system has been successfully applied to the synthesis of local anaesthetics intermediates also showing good productivity in recycling experiments.