133006-99-2

Upstream product

• 922-63-4 ethylacrolein 
• 96-22-0 pentan-3-one 
• 132950-82-4 (E)-(2S,3S,4S,8R,10S,11S)-11-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2,4,6,8,10-pentamethyl-12-methylene-9-oxo-tetradec-6-enethioic acid S-tert-butyl ester 
• 132970-62-8 (4S,5S)-5-Hydroxy-4-methyl-6-methylene-octan-3-one 
• 132950-85-7 (3R,4R)-4-((E)-(1R,5S,7R,8R)-8-Hydroxy-1,3,5,7-tetramethyl-9-methylene-6-oxo-undec-3-enyl)-3-methyl-oxetan-2-one 
• 132950-84-6 (3S,4S)-4-[(E)-(1S,5R,7S,8S)-8-(tert-Butyl-dimethyl-silanyloxy)-1,3,5,7-tetramethyl-9-methylene-6-oxo-undec-3-enyl]-3-methyl-oxetan-2-one 
• 132950-83-5 (E)-(2S,3S,4S,8R,10S,11S)-11-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2,4,6,8,10-pentamethyl-12-methylene-9-oxo-tetradec-6-enoic acid 
• 132950-79-9 (E)-(2S,6R,8S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-2,4,6,8-tetramethyl-10-methylene-7-oxo-dodec-4-enoic acid methyl ester 
• 132950-78-8 Propionic acid (1R,2R,4S,5S)-5-(tert-butyl-dimethyl-silanyloxy)-1-isopropenyl-2,4-dimethyl-6-methylene-3-oxo-octyl ester 
• 132950-80-2 (E)-(2S,6R,8S,9S)-9-(tert-Butyl-dimethyl-silanyloxy)-2,4,6,8-tetramethyl-10-methylene-7-oxo-dodec-4-enal 
• 132950-77-7 (3R,4R,6S,7S)-7-(tert-Butyl-dimethyl-silanyloxy)-3-hydroxy-2,4,6-trimethyl-8-methylene-dec-1-en-5-one 
• 132950-76-6 (4S,5S)-5-(tert-Butyl-dimethyl-silanyloxy)-4-methyl-6-methylene-octan-3-one 

Relevant academic research and scientific papers

Total synthesis of the esterase inhibitor (±)-ebelactone A using an aldol-Claisen strategy

The β-lactones (±)-ebelactone A has been prepared in 12 steps from diethylketone (9% overall yield) using a series of three boron enolate aldol reactions coupled with the Ireland ester enolate Claisen rearrangement, 10→11.