Total synthesis of the esterase inhibitor (±)-ebelactone A using an aldol-Claisen strategy

DOI: 10.1016/S0040-4039(00)88532-9

Source and publish data:

Tetrahedron Letters p. 7513 - 7516 (1990)

Update date:2022-08-03

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Authors:

Paterson

Hulme Hulme

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Article abstract of DOI:10.1016/S0040-4039(00)88532-9

The β-lactones (±)-ebelactone A has been prepared in 12 steps from diethylketone (9% overall yield) using a series of three boron enolate aldol reactions coupled with the Ireland ester enolate Claisen rearrangement, 10→11.

Full text of DOI:10.1016/S0040-4039(00)88532-9

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