Total synthesis of the esterase inhibitor (±)-ebelactone A using an aldol-Claisen strategy

Article abstract of DOI:10.1016/S0040-4039(00)88532-9

The β-lactones (±)-ebelactone A has been prepared in 12 steps from diethylketone (9% overall yield) using a series of three boron enolate aldol reactions coupled with the Ireland ester enolate Claisen rearrangement, 10→11.