1330184-65-0Relevant academic research and scientific papers
Access to N-cyanosulfoximines by transition metal-free iminations of sulfoxides
Dannenberg,Fritze,Krauskopf,Bolm
, p. 1086 - 1090 (2017/02/10)
A transition metal-free synthesis of N-cyanosulfoximines from sulfoxides using N-chlorosuccinimide (NCS) as oxidising agent and cyanamide as nucleophilic amine source is reported. The products are obtained in moderate to excellent yields. The protocol enables an easy access to N-cyanosulfoximines from readily available starting materials under inversion of configuration at a preexisting stereogenic center.
Bioactive sulfoximines: Syntheses and properties of Vioxx analogs
Park, Seong Jun,Buschmann, Helmut,Bolm, Carsten
, p. 4888 - 4890 (2011/09/21)
The syntheses and biological profiles of sulfoximine-based Vioxx analogs 2 are described. Interesting data have been obtained for 2a, which shows a selective COX-2 inhibition (albeit not as strong as Vioxx itself) exhibiting reduced hERG activity compare to the parent sulfone Vioxx (1).
