1330529-37-7 Usage
Description
1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE is an organic compound with the chemical formula C16H15NO2S. It is a highly reactive and versatile building block in organic synthesis, commonly used in the preparation of pharmaceuticals and agrochemicals. This chemical is characterized by its isocyanide functional group, which makes it a valuable reagent for the synthesis of a wide range of compounds. Additionally, its tosyl and tolyl moieties provide substituents that can impart specific properties to the resulting products. Due to its reactivity and potential applications, 1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE is an important compound in the field of organic chemistry and is utilized in various research and industrial processes.
Uses
Used in Pharmaceutical Industry:
1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE is used as a building block for the synthesis of pharmaceuticals, due to its reactivity and versatility in organic synthesis.
Used in Agrochemical Industry:
1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE is used as a building block for the synthesis of agrochemicals, due to its reactivity and versatility in organic synthesis.
Used in Organic Synthesis Research:
1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE is used as a reagent in the synthesis of a wide range of compounds, due to its isocyanide functional group and substituents provided by its tosyl and tolyl moieties.
Used in Industrial Processes:
1-P-TOLYL-1-TOSYLMETHYL ISOCYANIDE is used in various industrial processes, due to its reactivity and potential applications in the field of organic chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 1330529-37-7 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,0,5,2 and 9 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 1330529-37:
(9*1)+(8*3)+(7*3)+(6*0)+(5*5)+(4*2)+(3*9)+(2*3)+(1*7)=127
127 % 10 = 7
So 1330529-37-7 is a valid CAS Registry Number.
1330529-37-7Relevant articles and documents
Selective N-Terminal BET Bromodomain Inhibitors by Targeting Non-Conserved Residues and Structured Water Displacement**
Cui, Huarui,Divakaran, Anand,Pandey, Anil K.,Johnson, Jorden A.,Zahid, Huda,Hoell, Zachariah J.,Ellingson, Mikael O.,Shi, Ke,Aihara, Hideki,Harki, Daniel A.,Pomerantz, William C. K.
, p. 1220 - 1226 (2021)
Bromodomain and extra-terminal (BET) family proteins, BRD2-4 and T, are important drug targets; however, the biological functions of each bromodomain remain ill-defined. Chemical probes that selectively inhibit a single BET bromodomain are lacking, although pan inhibitors of the first (D1), and second (D2), bromodomain are known. Here, we develop selective BET D1 inhibitors with preferred binding to BRD4 D1. In competitive inhibition assays, we show that our lead compound is 9–33 fold selective for BRD4 D1 over the other BET bromodomains. X-ray crystallography supports a role for the selectivity based on reorganization of a non-conserved lysine and displacement of an additional structured water in the BRD4 D1 binding site relative to our prior lead. Whereas pan-D1 inhibitors displace BRD4 from MYC enhancers, BRD4 D1 inhibition in MM.1S cells is insufficient for stopping Myc expression and may lead to its upregulation. Future analysis of BRD4 D1 gene regulation may shed light on differential BET bromodomain functions.
COMPOUNDS FOR THE TREATMENT OF RESPIRATORY DISEASES
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, (2018/11/26)
The present invention relates to new compounds that are useful in the prevention or treatment of respiratory diseases, such as asthma, to the preparation of the compounds, and to compositions including the compounds. The present invention also relates to the use of the compounds, as well as compositions including the compounds, in treating or preventing respiratory diseases.
