133053-76-6

Basic information

• Product Name: 3-METHYL-6-NITROINDOLE
• Synonyms: 3-Methyl-6-nitro-1H-indole;3-Methyl-6-nitroindole
• CAS NO: 133053-76-6
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.18
• Mol File: 133053-76-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 365.5±22.0 °C(Predicted)
• Appearance: /
• Density: 1.355±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 15.06±0.30(Predicted)
• CAS DataBase Reference: 3-METHYL-6-NITROINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-METHYL-6-NITROINDOLE(133053-76-6)
• EPA Substance Registry System: 3-METHYL-6-NITROINDOLE(133053-76-6)

Safety Data

• Hazardous Substances Data: 133053-76-6(Hazardous Substances Data)

Usage

General Description

3-Methyl-6-nitroindole is a chemical compound that belongs to the class of indole derivatives. It is a nitro-substituted indole with a methyl group at the 3-position, and it is commonly used as a building block in the synthesis of various pharmaceuticals and agrochemicals. 3-METHYL-6-NITROINDOLE is known for its potential biological activities, including anti-inflammatory and anti-cancer properties. It has also been studied for its potential use in the development of new drugs for treating various diseases. Overall, 3-Methyl-6-nitroindole is an important chemical intermediate with promising applications in the field of medicinal chemistry and drug discovery.

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Relevant articles and documents

CARBOXAMIDE AND SULFONAMIDE DERIVATIVES USEFUL AS TEAD MODULATORS

The invention is concerned with the compounds of formula (I) and formula (II): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of using the compounds of formula (I) and formula (II) as well as pharmaceutical compositions containing such compounds. The compounds are useful in treating diseases and conditions mediated by TEAD, such as cancer.

Compositions for Treatment of Cystic Fibrosis and Other Chronic Diseases

The present invention relates to pharmaceutical compositions comprising an inhibitor of epithelial sodium channel activity in combination with at least one ABC Transporter modulator compound of Formula A, Formula B, Formula C, or Formula D. The invention also relates to pharmaceutical formulations thereof, and to methods of using such compositions in the treatment of CFTR mediated diseases, particularly cystic fibrosis using the pharmaceutical combination compositions.

MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS

The present invention relates to modulators of ATP-Binding Cassette (“ABC”) transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator, compositions thereof, and methods therewith. The present invention also relates to methods of treating ABC transporter mediated diseases using such modulators.