1330574-17-8

Basic information

• Product Name: ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate
• Synonyms: ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate
• CAS NO: 1330574-17-8
• Molecular Weight: 435.544
• Mol File: 1330574-17-8.mol

Chemical Properties

• CAS DataBase Reference: ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate(1330574-17-8)
• EPA Substance Registry System: ethyl 2-(5,6-dihydro-2-methyl-5-tosylphenanthridin-6-yl)acetate(1330574-17-8)

Safety Data

• Hazardous Substances Data: 1330574-17-8(Hazardous Substances Data)

Upstream product

• 1312447-90-7 N-Ts-4-methyl-2-phenylaniline 
• 140-88-5 ethyl acrylate 
• 583-68-6 2-bromo-p-toluidine 
• 42308-28-1 2-amino-5-methylbiphenyl 
• 98-80-6 phenylboronic acid 
• 87995-68-4 N-(2-bromo-4-methylphenyl)-4-methylbenzenesulfonamide 

Relevant articles and documents

A 6-substituted -5,6-b hydrogen phenanthridine method for preparing derivatives of

The invention relates to the field of organic synthesis, and particularly relates to a preparation method of a 6-substitute-5,6-dihydro phenanthridine derivative. The preparation method disclosed by the invention comprises the following steps of: carrying out Suzuki-Miyaura reaction and Michael addition reaction on phenylboronic acid ester II and an o-bromoaniline derivative III which used as raw materials in the presence of a palladium catalyst in a one-pot manner. The method has the advantages of easily available raw material, wide substrate application range, high yield, and the like.

Synthesis of 6-Substituted Phenanthridine Derivatives by Palladium-Catalysed Domino Suzuki-Miyaura/Aza-Michael Reactions

An efficient method for the synthesis of 6-substituted phenanthridine derivatives has been developed through a one-pot process involving a sequence of palladium-catalysed Suzuki-Miyaura reaction followed by intramolecular aza-Michael addition. This method is applicable to the synthesis of a wide range of substituted phenanthridines from simple substrates.

Pd-catalyzed sequential C-C and C-N bond formations for the synthesis of N-heterocycles: Exploiting protecting group-directed C-H activation under modified reaction conditions

Easy & efficient: A Pd-catalyzed domino olefination/conjugate addition reaction of N-Ts-2-arylanilines with activated olefins has been achieved at ambient temperature under the newly defined reaction conditions. This process highlighted the directing effect of the N-protecting group in C-H activation, displayed broad substrate scope with wide functional group compatibility; thus rendering a straightforward entry to a wide variety of N-heterocycles such as dihydrophenanthridines.