1330574-79-2

Basic information

• Product Name: 2-bromo-5-nitro-4-phenoxypyridine
• Synonyms: 2-bromo-5-nitro-4-phenoxypyridine
• CAS NO: 1330574-79-2
• Molecular Weight: 295.092
• Mol File: 1330574-79-2.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-bromo-5-nitro-4-phenoxypyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-bromo-5-nitro-4-phenoxypyridine(1330574-79-2)
• EPA Substance Registry System: 2-bromo-5-nitro-4-phenoxypyridine(1330574-79-2)

Safety Data

• Hazardous Substances Data: 1330574-79-2(Hazardous Substances Data)

Upstream product

• 108-95-2 phenol 
• 13091-23-1 4-chloro-3-nitropyridine 
• 132038-21-2 3-nitro-4-phenoxypyridine 
• 1330574-77-0 5-nitro-4-phenoxypyridin-2-ol 

Downstream Products

• 1330574-85-0 C₁₉H₁₇BrN₂O₂ 
• 1330574-88-3 C₂₁H₁₉BrN₂O₃ 
• 1330574-90-7 6-[18F]fluoro-PBR₂₈ 
• 1330574-82-7 5-amino-2-bromo-4-phenoxypyridine 

Relevant articles and documents

Novel 2,4,5-trisubstituted pyridines as key intermediates for the preparation of the TSPO ligand 6-F-PBR28: Synthesis and full 1H and 13C NMR characterization

As part of our ongoing research for molecular structures binding to the translocator protein (TSPO 18 kDa), we investigated the preparation of a number of new 2,4,5-trisubstituted pyridines as novel building blocks. In particular, 5-amino-2-halo-4-phenoxypyridines (11, 12, 13) were designed as key intermediates for the synthesis of the recently developed TSPO ligand 6-F-PBR28 and its fluorine-18-labeled version for positron emission tomography, 6-[ 18F]F-PBR28. We hereby report the chemical preparation as well as the 1H and 13C NMR spectroscopic data of polysubstituted pyridines 2, 3, 4, 5, 6, 7, 7b, 8, 9, 10, 11, 12, 13, 14. The latter demonstrates dramatic changes in electron density repartition of the aromatic ring upon substitution.