1330766-94-3Relevant articles and documents
Analysis of the structural and mechanistic factors in antioxidants that preserve mitochondrial function and confer cytoprotection
Arce, Pablo M.,Goldschmidt, Ruth,Khdour, Omar M.,Madathil, Manikandadas M.,Jaruvangsanti, Jennifer,Dey, Sriloy,Fash, David M.,Armstrong, Jeffrey S.,Hecht, Sidney M.
, p. 5188 - 5201 (2012/11/07)
Selected pyridinol analogues of the experimental neuroprotective drug idebenone have been synthesized and evaluated as antioxidants capable of preserving mitochondrial function. The compounds, having a different redox core but the same side chain as idebenone, exhibited a range of potencies, reflecting differences in their structures. The results obtained provide guidance in the design of such analogues with improved properties. Analogues were identified that have significantly improved antioxidant activity compared with idebenone in cultured lymphocytes, and which exhibit lesser inhibition of the electron transport chain.
MULTIFUNCTIONAL RADICAL QUENCHERS AND THEIR USE
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Page/Page column 59-60, (2011/09/19)
The present disclosure provides biologically active compounds of formula (I): and pharmaceutically acceptable salts thereof, compositions comprising these compounds, and methods of using these compounds in a variety of applications, such as treatment or suppression of diseases associated with decreased mitochondrial function resulting in diminished ATP production and/or oxidative stress and/or lipid peroxidation.
