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188826-32-6

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188826-32-6 Usage

Description

5-Fluoro-4-chromanone is a fluorinated heterocyclic compound with the chemical formula C9H7FO2. It features a chromanone core structure and is derived from 4-chromanone. 5-Fluoro-4-chromanone has garnered attention for its potential biological activities, including anti-cancer, anti-inflammatory, and antioxidant properties. As a building block in the synthesis of pharmaceutical compounds, 5-Fluoro-4-chromanone has demonstrated promise in preclinical studies as a therapeutic agent for a range of diseases. Its distinctive chemical characteristics render it an invaluable asset in medicinal chemistry research and drug discovery.

Uses

Used in Pharmaceutical Synthesis:
5-Fluoro-4-chromanone is utilized as a key building block in the development of novel pharmaceutical compounds due to its unique chemical properties and potential biological activities.
Used in Anticancer Research:
In the field of oncology, 5-Fluoro-4-chromanone is employed as a potential anti-cancer agent, leveraging its biological activities to target and combat cancer cells.
Used in Anti-inflammatory Applications:
5-Fluoro-4-chromanone is used as an anti-inflammatory agent, capitalizing on its ability to reduce inflammation which can be beneficial in treating various inflammatory conditions.
Used in Antioxidant Formulations:
5-Fluoro-4-chromanone is also used in antioxidant formulations to protect cells from oxidative stress, which is implicated in numerous diseases and aging processes.
Used in Medicinal Chemistry Research:
5-Fluoro-4-chromanone serves as a valuable tool in medicinal chemistry research, aiding scientists in understanding its structure-activity relationships and optimizing its therapeutic potential.
Used in Drug Discovery:
In the realm of drug discovery, 5-Fluoro-4-chromanone is applied to identify and develop new drug molecules with improved efficacy and safety profiles for the treatment of various diseases.

Check Digit Verification of cas no

The CAS Registry Mumber 188826-32-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,8,8,2 and 6 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 188826-32:
(8*1)+(7*8)+(6*8)+(5*8)+(4*2)+(3*6)+(2*3)+(1*2)=186
186 % 10 = 6
So 188826-32-6 is a valid CAS Registry Number.
InChI:InChI=1/C9H7FO2/c10-6-2-1-3-8-9(6)7(11)4-5-12-8/h1-3H,4-5H2

188826-32-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 18, 2017

Revision Date: Aug 18, 2017

1.Identification

1.1 GHS Product identifier

Product name 5-fluoro-2,3-dihydrochromen-4-one

1.2 Other means of identification

Product number -
Other names 5-Fluoro-4-Chromanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:188826-32-6 SDS

188826-32-6Relevant articles and documents

Synthesis, enantiomeric separation and docking studies of spiropiperidine analogues as ligands of the nociceptin/orphanin FQ receptor

Battisti, Umberto M.,Corrado, Sandra,Sorbi, Claudia,Cornia, Andrea,Tait, Annalisa,Malfacini, Davide,Cerlesi, Maria Camilla,Calò, Girolamo,Brasili, Livio

supporting information, p. 973 - 983 (2014/07/08)

A series of triazospirodecanone derivatives were synthesized as potential NOP ligands. 8-(Chroman-4-yl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-4-one (4) and its 5-fluoro analogue (18) proved to be active as agonists with EC50 values in the submicromolar range. Single enantiomers of compound 4 were separated and tested as NOP agonists; the eutomer R-(+)-4 showed a pEC 50 of 7.34. Finally docking studies were performed on the NOP receptor to identify the most significant stereospecific interactions.

SPIROAMINODIHYDROTHIAZINE DERIVATIVES

-

Page/Page column 61, (2010/04/03)

A compound represented by the general formula (I): or a pharmaceutically acceptable salt thereof, has an Aβ production inhibitory effect or a BACE1 inhibitory effect and is useful as a prophylactic or therapeutic agent for a neurodegenerative disease caused by Aβ and typified by Alzheimer- type dementia.

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