121702-60-1

Upstream product

• 133095-91-7 3,4,5-trimethoxyphenylmagnesium bromide 
• 133095-90-6 (S)-2-Bromo-5-(3-methanesulfonyl-5-methoxy-4-propoxy-phenyl)-tetrahydro-furan 
• 1136-86-3 methyl (3,4,5-trimethoxyphenyl) ketone 
• 5438-36-8 5-iodovaniline 
• 106331-89-9 3-methoxy-4-n-propyloxy-5-iodobenzaldehyde 
• 133095-95-1 4[3-Methoxy-4-n-propyloxy-5-iodophenyl]-4S-butyrolactone 
• 133095-94-0 (S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid 
• 113790-67-3 1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanedione 
• 116681-60-8 1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)-1,4-butanediol 
• 133095-96-2 (S)-5-(3-Methoxy-5-methylsulfanyl-4-propoxy-phenyl)-dihydro-furan-2-one 
• 116681-60-8 (1R,4RS)-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diol 
• 133095-89-3 tert-Butyl-[(S)-5-(3-methanesulfonyl-5-methoxy-4-propoxy-phenyl)-tetrahydro-furan-2-yloxy]-dimethyl-silane 
• 133095-93-9 (S)-4-Hydroxy-4-(3-iodo-5-methoxy-4-propoxy-phenyl)-butyric acid tert-butyl ester 
• 133117-06-3 (S)-5-(3-Methanesulfonyl-5-methoxy-4-propoxy-phenyl)-dihydro-furan-2-one 

Downstream Products

• 129314-27-8 trans-2-(3-methoxy-5-methylsulfonyl-4-n-propoxyphenyl)-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran 

Relevant academic research and scientific papers

Conversion of a silylated hemiacetal into an α-bromoether using trimethylsilylbromide. Synthesis of platelet activating factor antagonist L-659,989

An efficient synthesis of platelet activating factor antagonist L-659,989 has been achieved in ten steps from commercially available 5-iodovanillin. The key transformation converts a silylated hemi-acetal into an α-bromoether followed by a highly stereose

ENANTIOSELECTIVE CYCLIZATION OF CHIRAL BUTANE-1,4-DIOLS TO CHIRAL TETRAHYDROFURANS: SYNTHESIS OF CHIRAL TRANS-2-(3-METHOXY-5-METHYLSULFONYL-4-PROPOXYPHENYL-5-(3,4,5-TRIMETHOXYPHENYL)TETRAHYDROFURAN (L-659,989), A POTENT PAF-RECEPTOR ANTAGONIST

Acid catalyzed cyclization of (1R,4RS)- and(1S,4RS)-1-(3-methoxy-5-methylsulfonyl-4-propoxyphenyl)-4-(3,4,5-trimethoxyphenyl)butane-1,4-diols to the corresponding chiral cis- and trans-tetrahydrofurans proceeds with retention of configuration at C-1.Using