133097-30-0

Basic information

• Product Name: 1-(6-methoxy-2-naphthyl)ethanamine
• Synonyms: 1-(6-methoxy-2-naphthyl)ethanamine;UKRORGSYN-BB BBV-080514;1-(6-methoxy-2-naphthyl)ethanamine(SALTDATA: HCl);[1-(6-Methoxy-2-naphthyl)ethyl]aMine hydrochloride (SALTDATA: HCl)
• CAS NO: 133097-30-0
• Molecular Formula: C₁₃H₁₅NO
• Molecular Weight: 201.26
• Mol File: 133097-30-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 341.407°C at 760 mmHg
• Flash Point: 165.412°C
• Appearance: /
• Density: 1.089g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.608
• PKA: 9?+-.0.29(Predicted)
• CAS DataBase Reference: 1-(6-methoxy-2-naphthyl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(6-methoxy-2-naphthyl)ethanamine(133097-30-0)
• EPA Substance Registry System: 1-(6-methoxy-2-naphthyl)ethanamine(133097-30-0)

Safety Data

• Hazardous Substances Data: 133097-30-0(Hazardous Substances Data)

Usage

General Description

1-(6-methoxy-2-naphthyl)ethanamine is a chemical compound with a structure consisting of a naphthyl ring connected to an ethanamine group. It is also known as 6-methoxy-2-naphthylethylamine. 1-(6-methoxy-2-naphthyl)ethanamine is commonly used in research and pharmaceutical applications as a precursor for the synthesis of various target molecules. Its properties make it a valuable building block for the creation of new drugs and other biologically active compounds. As a result, 1-(6-methoxy-2-naphthyl)ethanamine is of interest to chemists and pharmacologists studying the development of potential pharmacological agents. Additionally, the presence of the methoxy (–OCH3) group on the naphthyl ring increases the compound's potential for various organic reactions and biological activities, further contributing to its widespread use in scientific research.

InChI:InChI=1/C13H15NO/c1-9(14)10-3-4-12-8-13(15-2)6-5-11(12)7-10/h3-9H,14H2,1-2H3

Upstream product

• 3893-38-7 1-(6-methoxynaphthalen-2-yl)ethanone oxime 
• 3900-45-6 6-methoxy-2-acetylnaphthalene 

Downstream Products

• 3900-45-6 6-methoxy-2-acetylnaphthalene 
• 132951-64-5 (S)-<1-(6-Methoxy-2-naphthyl)ethyl>amin 
• 132951-65-6 (R)-<1-(6-Methoxy-2-naphthyl)ethyl>amin 

Relevant articles and documents

The Direct Decarboxylative N-Alkylation of Azoles, Sulfonamides, Ureas, and Carbamates with Carboxylic Acids via Photoredox Catalysis

Herein, we describe a method for the direct decarboxylative C–N coupling of carboxylic acids with a range of nitrogen nucleophiles. This platform employs visible-light-mediated photoredox catalysis and an iodine(III) reagent to generate carbocation intermediates directly from aliphatic carboxylic acids via a radical-polar crossover mechanism. A variety of C–N bond-containing products are constructed from a diverse array of nitrogen heterocycles, including pyrazoles, imidazoles, indazoles, and purine bases. Furthermore, sulfonamides, ureas, and carbamates can also be utilized as the nucleophile to generate a selection of N-alkylated products. Notably, a two-step approach to construct free amines directly from carboxylic acids is accomplished using Cbz-protected amine as the nucleophile.

A base-mediated self-propagative Lossen rearrangement of hydroxamic acids for the efficient and facile synthesis of aromatic and aliphatic primary amines

A variety of aromatic and aliphatic hydroxamic acids were converted to the corresponding primary amines via base-mediated rearrangement. This rearrangement could proceed with less than 1 equiv. of K2CO3 in polar solvents under thermal conditions with no external reagents. This rearrangement has several features including no external activating agents needed for promoting the rearrangement, less than one equivalent of a base is sufficient for the reaction, and a clean reaction in which only carbon dioxide is produced as a by-product. A self-propagating mechanism via an isocyanate intermediate is proposed and elementary reaction steps, namely, chain propagation reactions are supported by experiments.

CATALYST COMPOUNDS

The present invention relates to an iridium-based catalyst compound for hydrogenating reducible moieties, especially imines and iminiums, the catalyst compounds being defined by the formula: (Formula (I)) where ring B is a conjugated ring system with one or more substituents. The catalysts of the invention are particularly effective in reductive amination procedures which involve the in situ generation of the imine or iminium under reductive hydrogenative conditions.