133099-12-4 Usage
Description
(R)-2,2-diphenyl-2-(pyrrolidin-3-yl)acetonitrile, with the molecular formula C21H20N2, is a chiral chemical compound that features a non-superimposable mirror image. This characteristic makes it a valuable building block in the realms of organic synthesis and medicinal chemistry. The presence of the pyrrolidine group in the molecule enhances its potential as a precursor for synthesizing a wide array of pharmaceutical compounds, thereby positioning it as a significant contributor to the field of medicinal chemistry and drug development.
Uses
Used in Pharmaceutical Development:
(R)-2,2-diphenyl-2-(pyrrolidin-3-yl)acetonitrile is used as a key building block for the development of new pharmaceuticals. Its unique structure allows it to target specific receptors or biological pathways, which is crucial for creating effective and selective medications.
Used in Medicinal Chemistry:
In the field of medicinal chemistry, (R)-2,2-diphenyl-2-(pyrrolidin-3-yl)acetonitrile serves as a valuable precursor for synthesizing various pharmaceutical compounds. Its chiral nature and the presence of the pyrrolidine group make it an attractive candidate for designing and creating novel drugs with improved efficacy and selectivity.
Used in Organic Synthesis:
(R)-2,2-diphenyl-2-(pyrrolidin-3-yl)acetonitrile is also utilized in organic synthesis, where its unique structural features can be exploited to create a diverse range of chemical products. Its applications in this industry are vast, as it can be used to develop new materials, catalysts, and other compounds with specific properties and functions.
Overall, (R)-2,2-diphenyl-2-(pyrrolidin-3-yl)acetonitrile is a versatile and promising compound with significant potential in various industries, particularly in the development of new pharmaceuticals and advancements in medicinal chemistry.
Check Digit Verification of cas no
The CAS Registry Mumber 133099-12-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,0,9 and 9 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 133099-12:
(8*1)+(7*3)+(6*3)+(5*0)+(4*9)+(3*9)+(2*1)+(1*2)=114
114 % 10 = 4
So 133099-12-4 is a valid CAS Registry Number.
133099-12-4Relevant articles and documents
Synthesis of Arylethylamines via C(sp3)-C(sp3) Palladium-Catalyzed Cross-Coupling
Lippa, Rhys A.,Battersby, David J.,Murphy, John A.,Barrett, Tim N.
, p. 3583 - 3604 (2021/02/27)
Substituted arylethylamines represent a key structural motif in natural, pharmaceutical, and agrochemical compounds. Access to such scaffolds has been the subject of long-standing synthetic interest. Herein, we report the synthesis of such scaffolds via a palladium-catalyzed C(sp3)-C(sp3) coupling between (chloromethyl)aryls and air-/moisture-stable N,N-dialkylaminomethyltrifluoroborate salts. Rapid hit identification was achieved using microscale high-throughput experimentation and was followed by millimolar-scale reaction parameter optimization. A range of structurally and electronically varied arylethylamine products were obtained in moderate to excellent yields (27-96%, >60 examples). The reaction mechanism is proposed to proceed via formation of a trialkylbenzylammonium species prior to oxidative addition.
METHOD OF PRODUCING (S)-3-(1-CYANO-1,1-DIPHENYLMETHYL)-PYRROLIDINE
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Page/Page column 14, (2010/12/30)
The present application relates to a method of (S)-3-(1-cyano-1,1-diphenylmethyl)-pyrrolidine by reacting an (S)-1-protected-3-(sulfonyloxy)-pyrrolidine having an easily deprotectable protecting group with diphenylacetonitrile in the presence of a base to obtain an (S)-1-protected-3-(1-cyano-1,1-diphenylmethyl)-pyrrolidine and then deprotecting the obtained compound under a mild condition. According to the method of the present invention, it is possible to efficiently produce (S)-3-(1-cyano-1,1-diphenylmethyl)-pyrrolidine, which is an important intermediate in the process of producing a muscarinic receptor antagonist such as darifenacin.
SUBSTITUTED PYRROLIDINES
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Page/Page column 32, (2009/01/24)
Disclosed herein are substituted pyrrolidine-based muscarinic receptor modulators of Formula I, process of preparation thereof, pharmaceutical compositions thereof, and methods of use thereof.
