13311-39-2Relevant academic research and scientific papers
Synthesis of non-cytotoxic poly(ester-amine) dendrimers as potential solubility enhancers for drugs: Methotrexate as a case study
Soto-Castro, Delia,Cruz-Morales, Jorge A.,Apan, Maria Teresa Ramirez,Guadarrama, Patricia
, p. 8082 - 8097 (2010)
This study describes the synthesis of two new families of dendrimers based on the esterification of N-alkylated 3-amine-1-propanol with two different cores, adipic acid (1st and 2nd generations) and ethylenediamine (generation 1.5), both with carboxylic acid end groups, offering a wide variety of further modifications at the periphery. According to the cytotoxic evaluation of the dendrimers and their possible degradation products within cell lines, these materials could be considered as innocuous. In preliminary studies, the synthesized dendrimers proved to be potential enhancers of solubility of highly hydrophobic drugs, like methotrexate, widely used in chemotherapy.
Supramolecular polymers based on high-density hydrogen bond interaction, and application thereof
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Paragraph 0087-0092, (2020/09/16)
The invention discloses compounds containing a tetracarboxyethyl diamine structure. The compounds have a structure represented by general formula shown in the specification, and in the general formulastructure, a bond like ~~ in the formula represents a molecular chain which has 8-12 main chain atoms and is formed by covalently connecting one or more of C, Si and O. The compound molecule forms asupramolecular polymer through a large number of hydrogen bonds, shows high mechanical strength at room temperature, has excellent environmental responsiveness, temperature sensitivity and self-repairability, and can be recycled and reprocessed for use.
A two-ethylene triamine derivatives, preparation method and application thereof
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Paragraph 0057; 0058; 0059; 0060; 0061; 0062; 0063, (2017/06/28)
The invention discloses diethylenetriamine derivatives, and a preparation method and application thereof. The diethylenetriamine derivatives are acids or soluble salts disclosed as chemical formula (I), wherein n is 0, 1, 2 or 3. The preparation method is implemented by carrying out Michael addition reaction on framework molecule and methyl acrylate. The diethylenetriamine derivatives disclosed by the invention are used for preparing a forward osmosis drawing solution, have the advantages of high safety, no toxicity, high water flux and low salt flowage, and greatly lower the energy consumption cost.
Hydroformylation of olefins using azoxy-dentated ligands
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, (2008/06/13)
At a temperature in the range 100° C to 225° C the destructive dissociation of cobalt carbonyl compounds to cobalt metal and residue is inhibited by the action of one or more azoxy-dentated chelation ligands.
