13312-85-1

Basic information

• Product Name: 2-hydroxy-2-(2-hydroxyphenyl)acetonitrile
• Synonyms: 2-hydroxy-2-(2-hydroxyphenyl)acetonitrile
• CAS NO: 13312-85-1
• Molecular Weight: 149.149
• Mol File: 13312-85-1.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 2-hydroxy-2-(2-hydroxyphenyl)acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-hydroxy-2-(2-hydroxyphenyl)acetonitrile(13312-85-1)
• EPA Substance Registry System: 2-hydroxy-2-(2-hydroxyphenyl)acetonitrile(13312-85-1)

Safety Data

• Hazardous Substances Data: 13312-85-1(Hazardous Substances Data)

Upstream product

• 74-90-8 hydrogen cyanide 
• 90-02-8 salicylaldehyde 
• 151-50-8 potassium cyanide 
• 28752-82-1 2-(allyloxy)benzaldehyde 
• 5804-85-3 diethylaluminium cyanide 
• 89-95-2 2-methyl-benzyl alcohol 
• 143-33-9 sodium cyanide 
• 613-90-1 benzoyl cyanide 

Downstream Products

• 17392-15-3 2-hydroxy-3(2H)-benzofuranone 
• 83530-80-7 α-(5-o-nitrophenyl-1,3,4-thiadiazol-2-yl-amino)-2-hydroxyphenylacetonitrile 
• 83530-89-6 α-(benzoylaminomethyl-1,3,4-thiadiazol-2-yl-amino)-2-hydroxyphenylacetonitrile 
• 125237-24-3 p,p'-bis(α-cyano(2-hydroxyphenyl)methylhydrazinocarbonylmethoxy)diphenyl sulphone 
• 115353-14-5 (1,5-Dimethyl-3-oxo-2-phenyl-2,3-dihydro-1H-pyrazol-4-ylamino)-(2-hydroxy-phenyl)-acetonitrile 
• 74552-60-6 2-Hydroxy-2-(2-hydroxyphenyl)-1-phenylethanone 

Relevant articles and documents

Cyanative alkene-aldehyde coupling: Ni(0)-NHC-Et2AlCN mediated chromanol synthesis with high cis-selectivity at room temperature

Described are several classes of Ni(0) mediated cyanative alkene-aldehyde coupling reactions, providing 6-membered cores, which complement existing cyclization technology in several respects. Et2AlCN was used as both a cyclization accelerator and CN source. The NHC ligand may have a positive effect in differentiating reductive elimination and syn-β-hydride elimination.

Synthesis and antimicrobial activity of some heterocyclic compounds

Condensation of 2-phenyl-3-(4-benzoyl hydride)-1,3-quinazolin-4(4H)-one (1) with various aldehydes gives 2-phenyl-3-(4-arylidene-benzoylhydrazide)-1,3-quinazolin-4(4H)-one (II), which on cycloaddition with mercaptoacetic acid yield 4-thiazolidinones (IIIa-o).Compound (I) on treatment with aromatic cyanohydrines and aryl isothiocyanates gives α-carbohydrazino nitriles of (IVa-m) and thiosemicarbazides (Va-l) respectively.The structures of III-V have been elucidated on the basis of their elemental analysis and spectral data.These compounds exhibit moderate to goodantibacterial and tuberculostatic activities.

Studies on Synthesis and Antimicrobial Evaluation of some New Thiophenol Derivatives

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