13314-67-5

Basic information

• Product Name: 1-Benzyl-4-(4-methylphenyl)tetrahydropyridine
• Synonyms: 1-BENZYL-4-(4-METHYLPHENYL)TETRAHYDROPYRIDINE;1,2,3,6-Tetrahydro-4-(4-Methylphenyl)-1-(phenylMethyl)pyridine
• CAS NO: 13314-67-5
• Molecular Formula: C₁₉H₂₁N
• Molecular Weight: 263.38
• Mol File: 13314-67-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 391.2 °C at 760 mmHg
• Flash Point: 170.5 °C
• Appearance: /
• Density: 1.063g/cm³
• Vapor Pressure: 2.5E-06mmHg at 25°C
• Refractive Index: 1.599
• PKA: 7.78±0.40(Predicted)
• CAS DataBase Reference: 1-Benzyl-4-(4-methylphenyl)tetrahydropyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Benzyl-4-(4-methylphenyl)tetrahydropyridine(13314-67-5)
• EPA Substance Registry System: 1-Benzyl-4-(4-methylphenyl)tetrahydropyridine(13314-67-5)

Safety Data

• Hazardous Substances Data: 13314-67-5(Hazardous Substances Data)

Usage

General Description

1-Benzyl-4-(4-methylphenyl)tetrahydropyridine is a chemical compound that is primarily used in research to study Parkinson's disease. It is a synthetic compound that acts as a neurotoxin, specifically targeting and destroying dopaminergic neurons in the brain, which are known to be affected in Parkinson's disease. 1-Benzyl-4-(4-methylphenyl)tetrahydropyridine is used in laboratory experiments to create animal models of Parkinson's disease and to study the neurobiology of the condition. Additionally, it is used to test potential treatments and therapies for the disease. Due to its toxicity, it is not used in clinical or therapeutic applications.

InChI:InChI=1/C19H21N/c1-16-7-9-18(10-8-16)19-11-13-20(14-12-19)15-17-5-3-2-4-6-17/h2-11H,12-15H2,1H3

Upstream product

• 1195-32-0 1-methyl-4-isopropenylbenzene 
• 13299-35-9 1-benzyl-4-(4-methylphenyl)piperidin-4-ol 
• 106-38-7 para-bromotoluene 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 126781-38-2 1-benzyl-4-(trifluoromethylsulfonyloxy)-1,2,5,6-tetrahydropyridine 
• 195062-57-8 p-tolylboronic pinacol ester 
• 106-43-4 para-chlorotoluene 
• 50-00-0 formaldehyd 
• 5720-05-8 4-methylphenylboronic acid 
• 107301-61-1 N-benzyl-4-amino-1-butyne 
• 936231-01-5 1-benzyl-4-(benzyldimethylsilanyl)-1,2,3,6-tetrahydro-pyridine hydrochloride 
• 624-31-7 4-tolyl iodide 

Downstream Products

• 874352-28-0 N-[1-benzyl-4-(4-methyl-phenyl)-piperidin-4-yl]-acetamide 
• 13314-68-6 C₁₉H₂₁N*ClH 
• 13299-35-9 1-benzyl-4-(4-methylphenyl)piperidin-4-ol 
• 109309-78-6 (1-Benzyl-4-p-tolyl-1,2,3,6-tetrahydro-[3]pyridyl)-methanol 

Relevant articles and documents

Synthesis and SAR study of 4-arylpiperidines and 4-aryl-1,2,3,6- tetrahydropyridines as 5-HT2C agonists

A series of substituted 4-arylpiperidines and a smaller family of 4-aryl-1,2,3,6-tetrahydropyridines were synthesized and their biological activity at the 5-HT2C receptor studied to determine whether either series showed noteworthy agonist activity. Structure-activity relationships were developed from the performed receptor binding assays and functional studies, and the results of the analysis are presented herein.

A strategy for isotope containment during radiosynthesis - Devolatilisation of bromobenzene by fluorous-tagging-Ir-catalysed borylation en route to the 4-phenylpiperidine pharmacophore

Syntheses of two 4-phenylpiperidines from bromobenzene have been developed involving anchoring to a fluorous-tag, Ir-catalysed borylation, Pd- and Co-catalysed elaboration then traceless cleavage. Although performed using 'cold' (i.e. unlabelled) bromoben

SYNTHESIS OF UNSATURATED PIPERIDINES FROM PIPERIDONES WITH A SILYL REAGENT

Syntheses of unsaturated piperidines from piperidones through a silyl pipehdine reagent via the Shapiro reaction and palladium-catalyzed cross- coupling reactions with organo halides.