133148-53-5Relevant academic research and scientific papers
One-step highly diastereoselective synthesis of γ-aminoalkyl-substituted γ-butyrolactones by an asymmetric samarium-mediated ketyl-alkene coupling reaction
Fukuzawa, Shin-Ichi,Miura, Manabu,Saitoh, Takahide
, p. 2042 - 2044 (2007/10/03)
The samarium(II) iodide mediated reaction of N,N-dibenzyl-protected (S)-α-amino aldehydes with (1S,2R)-N-methylephedrinyl acrylate gave the (4R, 1′S)-γ-(aminoalkyl)-γ-butyrolactones in good yields with high diastereoselectivities (up to 80% de); (4R, 1′S)γ-amino-(2-phenylethyl)-γ-butyrolactone (6a), which should be a potent precursor for γ-secretase inhibitors, was obtained with high de value.
Diastereoselective Synthesis of the Key Lactone Intermediate for the Preparation of Hydroxyethylene Dipeptide Isosteres
Lagu, Bharat R.,Liotta, Dennis C.
, p. 547 - 550 (2007/10/02)
An efficient and highly stereoselective route for preparing hydroxyethylene dipeptide isosteres from α-N,N-dibenzylamino ketones has been developed.
