133148-54-6

Basic information

• Product Name: (5R,1'S)-5-(1'-(dibenzylamino)-3'-methylbutyl)dihydrofuran-2(3H)-one
• Synonyms: (5R,1'S)-5-(1'-(dibenzylamino)-3'-methylbutyl)dihydrofuran-2(3H)-one
• CAS NO: 133148-54-6
• Molecular Weight: 351.489
• Mol File: 133148-54-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (5R,1'S)-5-(1'-(dibenzylamino)-3'-methylbutyl)dihydrofuran-2(3H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: (5R,1'S)-5-(1'-(dibenzylamino)-3'-methylbutyl)dihydrofuran-2(3H)-one(133148-54-6)
• EPA Substance Registry System: (5R,1'S)-5-(1'-(dibenzylamino)-3'-methylbutyl)dihydrofuran-2(3H)-one(133148-54-6)

Safety Data

• Hazardous Substances Data: 133148-54-6(Hazardous Substances Data)

Upstream product

• 111060-65-2 (S)-2-(dibenzylamino)-4-methylpentanal 
• 140-88-5 ethyl acrylate 
• 187600-79-9 (1S,2R)-N-methylephedrinyl acrylate 
• 52253-57-3 (1R,2S)-N-methylephedrinyl acrylate 

Relevant articles and documents

One-step highly diastereoselective synthesis of γ-aminoalkyl-substituted γ-butyrolactones by an asymmetric samarium-mediated ketyl-alkene coupling reaction

The samarium(II) iodide mediated reaction of N,N-dibenzyl-protected (S)-α-amino aldehydes with (1S,2R)-N-methylephedrinyl acrylate gave the (4R, 1′S)-γ-(aminoalkyl)-γ-butyrolactones in good yields with high diastereoselectivities (up to 80% de); (4R, 1′S)γ-amino-(2-phenylethyl)-γ-butyrolactone (6a), which should be a potent precursor for γ-secretase inhibitors, was obtained with high de value.

Stereocontrolled convergent synthesis of hydroxyethylene dipeptide isosteres by the reaction of α-amino aldehyde with alkoxytitanium homoenolates

The reaction of (S)-α-dibenzylamino aldehydes with dichloroisopropoxytitanium ester homoenolates gave the corresponding γ-aminoalkyl γ-lactones with high erythro selectivity. The same reaction by the use of amide homoenolates also afforded the correspondi