133149-66-3

Upstream product

• 30750-23-3 2-(4-oxo-3,4-dihydroquinazolin-2-yl)acetonitrile 
• 133149-49-2 (E)-3-(4-Chloro-phenyl)-2-(4-oxo-3,4-dihydro-quinazolin-2-yl)-acrylonitrile 
• 133149-54-9 (Z)-3-(4-Chloro-phenyl)-2-cyano-thioacrylimidic acid methyl ester 
• 118-92-3 anthranilic acid 
• 104-88-1 4-chlorobenzaldehyde 
• 2286-35-3 ethyl 3-(4-chlorophenyl)-2-cyanoacrylate 
• 39145-33-0 2-cyano-3-(4-chlorophenyl)-prop-2-enethioamide 

Relevant academic research and scientific papers

α-Cyanothioacetamide and its Derivatives in Heterocyclic Synthesis: Preparation of Several New 4-Oxoquinazoline Derivatives

The reaction of α-cyanothioacetamide (1) or its methylthio derivative (2) with anthranilic acid led to the formation of 3,4-dihydro-4-oxoquinazolin-2-yl acetonitrile (3). 3 condensed with aromatic aldehydes to give arylidene derivatives (4a-d) which could be prepared also via the reaction of 2-thiocarbamoylcinnamonitriles (5a-d) or their methylthio derivatives (6a-d) with anthranilic acid. 3 reacted with cinnamonitrile derivatives (7a-h) and (12a-d) to yield pyrido--quinazoline derivatives (10a-h) and (15a-d) which could also be prepared by the reaction of (4a-d) with malononitrile (11a), benzoyl acetonitrile (11b) and ethylcyanoacetate (16), respectively.