133186-55-7

Basic information

• Product Name: 3'',5''-Difluoro-4''-Hydroxyacetophenone
• Synonyms: 3'',5''-Difluoro-4''-Hydroxyacetophenone;1-(3,5-Difluoro-4-hydroxyphenyl)ethanone
• CAS NO: 133186-55-7
• Molecular Formula: C₈H₆F₂O₂
• Molecular Weight: 172.129
• Mol File: 133186-55-7.mol
• Article Data: 6

Chemical Properties

• Appearance: /
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 3'',5''-Difluoro-4''-Hydroxyacetophenone(CAS DataBase Reference)
• NIST Chemistry Reference: 3'',5''-Difluoro-4''-Hydroxyacetophenone(133186-55-7)
• EPA Substance Registry System: 3'',5''-Difluoro-4''-Hydroxyacetophenone(133186-55-7)

Safety Data

• Hazardous Substances Data: 133186-55-7(Hazardous Substances Data)

Usage

Preparation

Preparation by Fries rearrangement of 2,6-difluorophenyl acetate (b.p.7 62–63°) with aluminium chloride at 140–150° for 5 h under nitrogen atmosphere (56%).

Upstream product

• 36914-78-0 2',6'-difluorophenyl acetate 
• 99-93-4 4-Hydroxyacetophenone 
• 170570-79-3 1-(3,5-difluoro-4-methoxy-phenyl)ethanone 
• 28177-48-2 2,6-difluorophenol 

Downstream Products

• 386213-25-8 4-(2-bromo-ethoxy)-3,5-difluoro-benzoic acid ethyl ester 
• 386213-28-1 1-[4-(2-bromo-ethoxy)-3,5-difluoro-phenyl]-ethanone 

Relevant articles and documents

Synthesis of pentafluorobenzyloxy mono- to tetrafluoroacetophenones

Pentafluorobenzyloxyacetophenones are formed by reacting 2',3',4',5',6'-pentafluoroacetophenone and 2',3',4',5'-tetrafluoroacetophenone with pentafluorobenzyl alcohol (PFBA) in refluxing toluene under phase-transfer conditions.This provided seven new such

SELECTIVE OCTAHYDRO-CYCLOPENTA[C] PYRROLE NEGATIVE MODULATORS OF NR2B

Compounds that selectively negatively modulate NMDA receptors containing an NR1/NR2B subunit, pharmaceutical compositions comprising the compounds, and methods of treating a disease using the compounds are disclosed. Such diseases include, without limitation, neurological dysfunction such as Parkinson's disease, Huntington's disease, amyotrophic lateral sclerosis, multiple sclerosis, and seizure disorders; emotional disorders; depression; bipolar disorder; obsessive-compulsive disorder; and other anxiety disorders.

Elemental fluorine Part 12. Fluorination of 1,4-disubstituted aromatic compounds

Direct fluorination of a series of 1,4-disubstituted benzene derivatives in acid reaction media at convenient temperature leads, in many cases, to selectively fluorinated aromatic products in preparatively useful conversions and yields.