133216-45-2

Usage

Uses

Used in Pharmaceutical Industry:
L-697818 is used as an impurity in Finasteride, which is a medication for treating benign prostatic hyperplasia (BPH) and male pattern hair loss. As an inhibitor of 5α-reductase, Finasteride helps reduce the levels of dihydrotestosterone (DHT), leading to decreased prostate size and improved hair growth in men with androgenetic alopecia.
Used in Hair Loss Treatment:
L-697818 is used as an antialopecia agent for promoting hair growth and preventing hair loss in individuals suffering from androgenetic alopecia. By inhibiting the 5α-reductase enzyme, it helps reduce DHT levels, which is believed to contribute to hair follicle miniaturization and hair loss.

Upstream product

• 129273-17-2 (4aR,4bS,6aS,7S,9aS,9bS,11aR)-7-(Imidazole-1-carbonyl)-4a,6a-dimethyl-1,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-indeno[5,4-f]quinolin-2-one 
• 103335-55-3 3-oxo-4-aza-5α-androstane-17β-carboxylic acid 
• 73671-92-8 3-oxo-4-aza-5α-androstane-17β-carboxylic acid methyl ester 
• 104239-97-6 3-Oxo-4-aza-5α-androst-1-ene-17β-carboxylic acid 

Relevant academic research and scientific papers

Impurities in finasteride: Identification, synthesis, characterization and control of potential carry-over impurities from reagents used for the process

An assessment of the impurity profile of finasteride and possible carry-over related substances likely to arise during the synthesis of finasteride is described in this article. Impurities in reaction mass were monitored by HPLC, potential impurities isolated with preparative HPLC and structures were substantiated by 1H NMR, MS and MS-MS. Impurities RRT's were established by HPLC co-injection. Based on the spectral data structure of impurity I and impurity II were characterized as cyclohexyl and phenyl analog of finasteride.

Acylimidazolides as Versatile Synthetic Intermediates for the Preparation of Sterically Congested Amides and Ketones: A Practical Synthesis of Proscar

Acylimidazolides react with magnesium amides to produce carboxamides in excellent yields, whereas Fe(III) catalyzed cross coupling between acylimidazolide and Grignard reagents produce ketones in high yields.These methods were utilized to prepare the α-reductase inhibitor Proscar as well as various 17β-amide and ketone analogs of Δ1-4-aza-5α-androsten-3-one.