104239-97-6 Usage
Chemical Properties
4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid is Off-White Powder
Uses
Different sources of media describe the Uses of 104239-97-6 differently. You can refer to the following data:
1. 4-Aza-5a-androstan-1-ene-3-one-17b-carboxylic acid is an intermediate in the synthesis of Finasteride, am onhibitor of 5a-reductase, the enzyme which converts testosterone to the more potent androgen, 5a-dihydrotestosterone
2. A novel intermediate in the synthesis of Finasteride, a 5α-reductase inhibitor used for treatment of benign prostatic hyperplasia acne, seborrhea, female hirsutism, prostatitis, and prostatic carcinoma and other hyperandrogenetic related disorders.
3. A novel intermediate in the synthesis of Finasteride and Dutasteride, a 5α-reductase inhibitors used for treatment of benign prostatic hyperplasia acne, seborrhea, female hirsutism, prostatitis, and p
rostatic carcinoma and other hyperandrogenetic related disorders.
Check Digit Verification of cas no
The CAS Registry Mumber 104239-97-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,4,2,3 and 9 respectively; the second part has 2 digits, 9 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 104239-97:
(8*1)+(7*0)+(6*4)+(5*2)+(4*3)+(3*9)+(2*9)+(1*7)=106
106 % 10 = 6
So 104239-97-6 is a valid CAS Registry Number.
InChI:InChI=1/C19H27NO3/c1-18-9-7-13-11(12(18)4-5-14(18)17(22)23)3-6-15-19(13,2)10-8-16(21)20-15/h8,10-15H,3-7,9H2,1-2H3,(H,20,21)(H,22,23)/t11-,12-,13-,14+,15+,18-,19+/m0/s1
104239-97-6Relevant articles and documents
A scaleable synthesis of dutasteride: A selective 5α-reductase inhibitor
Satyanarayana, Komati,Srinivas, Katkam,Himabindu, Vurimidi,Reddy, Ghanta Mahesh
, p. 842 - 845 (2007)
An improved and scaleable process for Dutasteride (1), a synthetic 4-azasteroid derivative essentially used for the treatment of prostate diseases, is described
Production process of high-purity dutasteride
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Paragraph 0046; 0052; 0057, (2018/04/02)
The invention discloses a purification production process of high-purity dutasteride. The problems to be solved are that the purity of the dutasteride is improved while the production cost is reduced.According to the method, after a dutasteride crude product is obtained, twice crystallization is carried out, so that the dutasteride with high yield and high purity can be obtained. The production process provided by the invention has the advantages of high efficiency and clean production, and the operability is high. An intermediate is refined, so that the quality of the dutasteride finished product is more easily controlled, the purity of the obtained dutasteride product is not lower than 99.5%, and any single impurity in the product is not higher than 0. 1%.
PROCESS FOR PREPARING ANDROSTENONE DERIVATIVES
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Page/Page column 17, (2012/04/04)
Provided is a process for preparing androstenone derivatives, specifically 3-oxo-4-aza-5α-androstene-17β-carboxylic acid of Formula I, a key intermediate for dutasteride.
